Permselective structurally robust membrane material

• US 7,157,528 B2
• Filed: 05/21/2004
• Issued: 01/02/2007
• Est. Priority Date: 05/21/2003
• Status: Active Grant

• Current Assignee: Konamite Limited
• Original Assignee: Polymer Technology Group, Inc. (DSM-Firmenich AG)
• Inventors: Ward, Robert S.
• Primary Examiner(s): Peng; Kuo-Liang
• Application Number:
  US10/851,809
• Publication Number:
  US 20050004324A1
• Time in Patent Office: 956 Days
• Field of Search: 525/474, 525/462, 600/347, 204/403.11
• US Class Current: 525/474
• CPC Class Codes: A61B 5/1486 using enzyme electrodes, e.g. with immobilised oxidase
• CPC Class Codes: C08G 18/283 Compounds containing ether groups, e.g. oxyalkylated monohydroxy compounds
• CPC Class Codes: C08G 18/3206 aliphatic
• CPC Class Codes: C08G 18/4018 Mixtures of compounds of group C08G18/42 with compounds of group C08G18/48
• CPC Class Codes: C08G 18/44 Polycarbonates
• CPC Class Codes: C08G 18/61 Polysiloxanes
• CPC Class Codes: C08G 77/42 Block-or graft-polymers containing polysiloxane sequences polymerising aliphatic unsaturated monomers on to a polysiloxane C08F283/12
• CPC Class Codes: C08G 77/448 containing polycarbonate sequences
• CPC Class Codes: C08G 77/458 containing polyurethane sequences
• CPC Class Codes: C08G 77/46 containing polyether sequences
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: G01N 33/54373 involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Abstract

A biocompatible multipolymer, having a backbone comprising about 10 to 45 wt % of at least one hard segment and about 55 to 90 wt % of soft segments. The soft segments are divided into three groups, 5 to 25 wt %, of total soft segment weight, of an oxygen permeable soft segment; 5 to 25 wt %, of total soft segment weight, of a hydrophilic soft segment; and 50 to 90 wt %, of total soft segment weight, of a biostable, relatively hydrophobic soft segment.

Claims

1. A biocompatible multipolymer, having a backbone comprising:

(a) about 10 to 45 wt % of at least one hard segment;

(b) about 55 to 90 wt % of soft segments, including;

(i) 5 to 25 wt %, of total soft segment weight, of an oxygen permeable soft segment;

(ii) 5 to 25 wt %, of total soft segment weight, of a hydrophilic soft segment;

(iii) 50 to 90 wt %, of total soft segment weight, of a biostable, hydrophobic soft segment; and

(c) having water absorption of from 2 to 25% of weight in membrane form.

2. The multipolymer of claim 1, wherein said biostable, hydrophobic soft segment is a polycarbonate.

3. The multipolymer of claim 1, wherein said hydrophilic soft segment has the chemical form O(CH₂)_N, where N<

4.

4. The multipolymer of claim 3, wherein said hydrophilic soft segment is polyethylene oxide.

5. The multipolymer of claim 1, wherein said oxygen-permeable soft segment is polydimethylsiloxane.

6. The multipolymer of claim 1, further comprising capping end groups.

7. The multipolymer of claim 6, wherein said capping end groups comprise less than about 10 wt % of the total weight of said multi polymer.

8. The multipolymer of claim 1, capable of forming a membrane having a tensile strength of from 300 to 1,000 psi.

9. The multipolymer of claim 1, capable of forming a membrane having an ultimate elongation of 100 to 1,000%.

10. A glucose sensor, which senses glucose by way of oxidation and which includes a membrane that is permselective of oxygen and glucose, said membrane comprising:

a biocompatible multipolymer having water absorption of from 2 to 25% of dry weight in membrane form, and having a backbone comprising about 55 to 90 wt % of soft segments including;

(i) 5 to 25 wt %, of total soft segment weight, of an oxygen permeable soft segment;

(ii) 5 to 25 wt %, of total soft segment weight, of a hydrophilic soft segment; and

(iii) 50 to 90 wt %, of total soft segment weight, of a biostable, hydrophilic soft segment.