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Mixed mode microfluidic systems

  • US 7,160,423 B2
  • Filed: 03/04/2003
  • Issued: 01/09/2007
  • Est. Priority Date: 03/05/2002
  • Status: Active Grant
First Claim
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1. A method of at least partially separating at least first and second species in a sample mixture, the first species having a lower electrophoretic mobility than the second species, the method comprising:

  • providing a device having at least first, second and third channel segments fluidly coupled at a first fluid junction;

    applying a pressure gradient between said first and second channel segments; and

    applying a voltage gradient between said second and third channel segments whereby at least a portion of the first species flows into the second channel segment while at least a potion of the second species flows into the third channel segment.

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