Apparatus and applicator patch for transdermal substance delivery

• US 7,162,297 B2
• Filed: 07/12/2001
• Issued: 01/09/2007
• Est. Priority Date: 09/22/2000
• Status: Expired due to Fees

• Current Assignee: Elisabetta Rossi
• Original Assignee: Elisabetta Rossi
• Inventors: Rossi, Elisabetta
• Primary Examiner(s): WILLIAMS, CATHERINE SERKE
• Application Number:
  US10/381,255
• Publication Number:
  US 20030176832A1
• Time in Patent Office: 2,007 Days
• Field of Search: 604/20, 604/501, 435/173.7, 435/173.5, 435/173.6, 204/450
• US Class Current: 604/20
• CPC Class Codes: A61N 1/044 Shape of the electrode
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428

Abstract

Apparatus for transdermal delivery of substances contained in a carrier fluid, comprising a power supply unit which supplies an electric signal to at least two electrodes connected thereto. The electric signal is a modulated oscillating signal and the electrodes are arranged in respective patches. The apparatus may be used for the transdermal delivery of substances such as, for example, active principles for therapeutic and cosmetic use.

Claims

1. Apparatus for transdermal delivery of a substance contained in a carrier fluid, comprising a power supply unit which supplies a modulated oscillating electric signal to electrodes connected thereto, wherein at least two of said electrodes are arranged in respective patches with electrodes on a same patch having the same polarity, and wherein each patch comprises a flexible, closed, wrapping which can be filled with a fluid carrying the substance to be delivered and has a wall which is permeable to said substance.

2. Apparatus according to claim 1, wherein said electric signal has an oscillating frequency of between 50 and 3,000 Hz.

3. Apparatus according to claim 2, wherein the oscillating electric signal is amplitude modulated with a periodic pulsating profile.

4. Apparatus according to claim 3, wherein the pulsating profile for the modulation of the signal has a pulsation duration (Tp) of between 0.5 and 10 seconds.

5. Apparatus according to claim 4, wherein the polarity of the signal applied to an electrode is reversed after a predefined time interval.

6. Apparatus according to claim 1, wherein said power supply unit supplies said oscillating electric signal in temporal succession to a plurality of electrodes connected thereto.

7. Apparatus according to claim 1, wherein each of said at electrodes has a surface area of between 0.5 and 5 cm².

8. Apparatus according to claim 1, wherein the patch is to be applied onto a part of the body to be treated.

9. Apparatus according to claim 8, wherein the patch comprises a band of flexible textile and/or polymer material onto which the electrodes are applied.

10. Apparatus according to claim 9, wherein the electrodes are removably connected, by means of respective fastenings, to electric wires for connection to the power supply unit.

11. Apparatus according to claim 1, wherein the wall permeable to the substance to be delivered is formed by means of one or more systems selected from a perforated meshwork, an osmotic membrane, and a sheet with holes passing there through.

12. Apparatus according to claim 1, comprising a compressor associated with the power supply unit, whose delivery is connected to a reservoir communicating with the wrapping of the patch.

13. Patch for an apparatus according to claim 1, comprising a flexible band of textile and/or polymer material, with a plurality of electrodes associated thereto, said electrodes having respective pins which project from the band and can be connected to a unit supplying an electric signal.

14. Patch for an apparatus according to claim 1, comprising a substantially closed, flexible, wrapping with a wall which is permeable to the substance to be delivered.

15. Patch according to claim 14, comprising a plurality of electrodes fixed to the wrapping in a position opposite to said permeable wall.

16. Patch according to claim 14, comprising a plurality of openings passing through the wrapping for the insertion of plugs.

17. Patch according to claim 13, wherein an adhesive edge is present along the periphery of the band or of the permeable wall.

18. Patch according to claim 13, wherein the band or the wrapping provided with belts or other securing means for the attachment to a part of the body.

19. Patch according to claim 13, wherein the band or the wrapping have an anatomical configuration corresponding to the part of the body for which they intended.

20. Patch according to claim 13, wherein freeze-dried or gelified material is applied on the band or on the wrapping.