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Controlled release microencapsulated NGF formulation

  • US 7,163,701 B2
  • Filed: 05/20/2003
  • Issued: 01/16/2007
  • Est. Priority Date: 06/13/1997
  • Status: Expired due to Fees
First Claim
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1. A polymeric microsphere device having a diameter of less than about 1000 microns for sustained controlled release of NGF and another neurotrophic factor selected from NT-3, NT-4/5, BDNF, and combinations thereof, comprising a biocompatible polymeric microsphere containing about 0.1% to about 50% NGF by weight complexed with an NGF-stabilizing metal that binds NGF, and another neurotrophic factor selected from NT-3, NT-4/5, BDNF, and combinations thereof, which device is capable of releasing NGF over a period of time in excess of about one day.

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