Ion exchange cryptands covalently bound to substrates

• US 7,166,226 B2
• Filed: 01/28/2005
• Issued: 01/23/2007
• Est. Priority Date: 09/07/2001
• Status: Expired due to Term

• Current Assignee: Dionex Corporation (Thermo Fisher Scientific Incorporated)
• Original Assignee: Dionex Corporation (Thermo Fisher Scientific Incorporated)
• Inventors: Bordunov, Andrei V., Pohl, Christopher A., Woodruff, L. Andy
• Primary Examiner(s): Barry; Chester T.
• Application Number:
  US11/046,477
• Publication Number:
  US 20050133453A1
• Time in Patent Office: 725 Days
• Field of Search: 210683-684, 536/103, 540/145, 549/10, 549/347, 549/348
• US Class Current: 210/683
• CPC Class Codes: B01J 41/14 obtained by reactions only involving unsaturated carbon-to-carbon bonds
• CPC Class Codes: B01J 45/00 Ion-exchange in which a complex or a chelate is formed; Use of material as complex or chelate forming ion-exchangers; Treatment of material for improving the complex or chelate forming ion-exchange properties ion-exchange chromatography processes B01D15/36

Abstract

One embodiment of the invention comprises an ion exchange composition formed by reacting unsaturated carbon to carbon moieties pendant from derivatized ion binding cryptands with a support substrate under free radical activation conditions to form a covalent bond therebetween. In another embodiment, a cryptand ion exchange composition is made by covalently bonding unsaturated carbon to carbon moieties pendant from a derivatized ion binding cryptands with unsaturated carbon to carbon moieties pendant from a support substrate under free radical activation conditions to form covalent bond.

Claims

1. A method for making a cryptand ion exchange composition comprising:

covalently bonding unsaturated carbon to carbon moieties pendant from a derivatized ion binding cryptands with unsaturated carbon to carbon moieties pendant from a support substrate under free radical activation conditions to form covalent bond.

2. The method of claim 1 in which said cryptand pendant carbon to carbon moiety is on a styrenic group.

3. The method of claim 1 in which said derivatized cryptand is the only ion binding moiety bound to said polymeric substrate.

4. The method of claim 1 in which said ion exchange composition comprises multiple cryptands projecting from each of said support substrates as strands of a brush polymer, said ion exchange composition having an ion binding constant of at least about 1000 in water.

5. The method of claim 1 in which said ion exchange composition comprises multiple cryptands projecting from each of said support substrates as strands of a brush polymer, said support substrates being in the form of a particulate resin bed comprising a chromatographic separation packed bed.

6. The method of separating anions in a liquid sample comprising flowing said liquid sample through a flowthrough bed of ion exchange composition made by the method of claim 1 to separate said anions.

7. The method of separating anions in a liquid sample comprising flowing said liquid sample through a flowthrough bed of ion exchange composition made by the method of claim 2 to separate said anions.

8. The method of separating anions in a liquid sample comprising flowing said liquid sample through a flowthrough bed of ion exchange composition made by the method of claim 3 to separate said anions.

9. The method of separating anions in a liquid sample comprising flowing said liquid sample through a flowthrough bed of ion exchange composition made by the method of claim 4 to separate said anions.

10. The method of separating anions in a liquid sample comprising flowing said liquid sample through a flowthrough bed of ion exchange composition made by the method of claim 5 to separate said anions.