Combination growth factor therapy and cell therapy for treatment of acute and chronic heart disease
First Claim
1. A method for the systemic, multi-tiered treatment of acute and chronic cardiomyopathy by delivering a formulation comprising one or more therapeutic growth factor proteins together with adult stem cells, the method comprising the steps of:
- a) selecting a patient displaying symptoms of acute or chronic cardiomyopathy;
b) administrating at least one dose of an effective amount of a first therapeutic growth factor protein formulation comprising a growth factor protein being selected from the group consisting of FGF-1, FGF-2, VEGF, VEGFA, VEGF165, and mixtures thereof by inhalation therapy;
c) following administration of at least one dose of an effective amount of a first therapeutic growth factor protein formulation, administrating at least one dose of an effective amount of adult stem cells;
d) monitoring the effectiveness of administration of adult stem cells by echo-cardiogram and/or other clinical indictors;
e) determining, based on monitoring the effectiveness of stem cell treatment by echo-cardiogram, whether an additional dose of stem cells is necessary or whether an additional dose of growth factor protein is indicted;
f) depending on the results of the step e), administering a second dose of an effective amount of adult stem cells and or growth factor proteins; and
g) if indicated, repeating steps b) through e) until there is a clinical indication of amelioration of amelioration of the symptoms of acute or chronic heart disease in the patient, or until there is contraindication to continued treatment.
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Accused Products
Abstract
Acute and chronic heart disease is treated using a rational, multi-tier approach. A patient is pretreated with growth factor proteins or gene therapy, followed by the administration of adult stem cells. The progress of treatment is continuously monitored by echo-cardiogram with growth factor treatment and/or stem cell administration adjusted according to the results of the echo-cardiogram or clinical status of the patient. Heart disease is also treated by a method that comprises administration of a therapeutically effective amount of a growth factor protein by oral inhalation therapy.
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Citations
21 Claims
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1. A method for the systemic, multi-tiered treatment of acute and chronic cardiomyopathy by delivering a formulation comprising one or more therapeutic growth factor proteins together with adult stem cells, the method comprising the steps of:
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a) selecting a patient displaying symptoms of acute or chronic cardiomyopathy; b) administrating at least one dose of an effective amount of a first therapeutic growth factor protein formulation comprising a growth factor protein being selected from the group consisting of FGF-1, FGF-2, VEGF, VEGFA, VEGF165, and mixtures thereof by inhalation therapy; c) following administration of at least one dose of an effective amount of a first therapeutic growth factor protein formulation, administrating at least one dose of an effective amount of adult stem cells; d) monitoring the effectiveness of administration of adult stem cells by echo-cardiogram and/or other clinical indictors; e) determining, based on monitoring the effectiveness of stem cell treatment by echo-cardiogram, whether an additional dose of stem cells is necessary or whether an additional dose of growth factor protein is indicted; f) depending on the results of the step e), administering a second dose of an effective amount of adult stem cells and or growth factor proteins; and g) if indicated, repeating steps b) through e) until there is a clinical indication of amelioration of amelioration of the symptoms of acute or chronic heart disease in the patient, or until there is contraindication to continued treatment. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification