Method of treating symptoms of common cold, allergic rhinitis and infections relating to the respiratory tract

• US 7,166,640 B2
• Filed: 07/23/2001
• Issued: 01/23/2007
• Est. Priority Date: 07/28/2000
• Status: Expired due to Fees

• Current Assignee: Immupharm APS
• Original Assignee: Immupharm APS
• Inventors: Berg, Kurt Frimman
• Primary Examiner(s): HUI, SAN MING R
• Application Number:
  US10/363,430
• Publication Number:
  US 20040053858A1
• Time in Patent Office: 2,010 Days
• Field of Search: 514/456
• US Class Current: 514/456
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/35 having six-membered rings with one oxygen as the only ring hetero atom
• CPC Class Codes: A61K 31/7048 having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin , digitoxin or digoxin
• CPC Class Codes: A61K 33/30 Zinc; Compounds thereof
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/02 Nasal agents, e.g. decongestants
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 27/00 Drugs for disorders of the senses
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 31/16 for influenza or rhinoviruses
• CPC Class Codes: A61P 37/00 Drugs for immunological or allergic disorders
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14

Abstract

The present invention relates to methods of treating conditions and/or symptoms related to common cold of the upper and/or lower respiratory tract and/or eyes. In particular the invention relates to the methods of treating conditions and/or symptoms related to common cold comprising administration of a flavonoid or administration of a flavonoid in combination with a metal. The invention furthermore describes compositions comprising a metal and a flavonoid useful for the treatment of conditions and/or symptoms relates to common cold.

Claims

1. A method of treatment of symptoms selected from the group consisting of cough, sneezing, muscle pain, sore throat, hoarseness, headache, malaise, chilliness, nasal discharge, nasal obstruction, pain relating to the sinuses, rhinitis, swelling of mucosal membranes, pharyngitis and bronchitis, comprising administering to an individual in need thereof a therapeutically effective dosage of a pharmaceutically acceptable composition comprising at least one flavonoid which is a hydroxyethylrutoside, or a salt thereof.

2. The method according to claim 1 wherein the pharmaceutical composition does not comprise any vitamin.

3. The method according to claim 1 wherein at least one flavonoid is troxerutin of the formula:

4. The method according to claim 1, wherein said composition comprises mono-, di-, tri- and tetrahydroxyethyl rutosides.

5. The method according to claim 1, wherein the treatment is in combination with a second treatment, wherein the second treatment comprises administration of a therapeutic agent selected from the group consisting of oseltamivir phosphate, pleconaril, interferons, and rimantadine.

6. The method according to claim 1, wherein the treatment is in combination with a second treatment, wherein the second treatment comprises administration of a pharmaceutically acceptable Zn²⁺ salt and/or complex.

7. The method of claim 1 wherein said composition further comprises a pharmaceutically acceptable metal complex.

8. The method of claim 1 in which said individual is suffering from common cold.

9. The method of claim 1 in which said individual is suffering from a viral infection of the upper and/or lower respiratory tract, and/or eyes.

10. The method according to claim 9, wherein the viral infection is caused by one or more viruses selected from the group consisting of adenoviruses, parvoviruses, picornaviruses, reoviruses, orthomyxoviruses, paramyxoviruses, arenaviruses, caliciviruses, coronaviruses, rhinovirus, influenza virus, echovirus, respiratory syncytial virus (RSV) and coxsackie virus.

11. The method according to claim 9, wherein the infection is caused by one or more viruses selected from the group consisting of coronaviruses and rhinoviruses.

12. The method according to claim 10, wherein the influenza virus is selected from the group consisting of influenza virus type A and influenza virus type B.

13. The method of claim 1 in which said individual is suffering from a bacterial infection of the upper and/or lower respiratory tract, and/or eyes.

14. The method of claim 1 in which said individual is suffering from rhinitis.

15. The method of claim 1 in which said individual is suffering from hay fever.

16. The method of claim 9 in which the viral infection is secondary to the common cold.

17. The method of claim 13 in which the bacterial infection is secondary to the common cold.

20. The method of claim 1 in which at least one of said symptoms is attributable, at least in part, to a common cold.

21. The method of claim 3 in which said individual is suffering from common cold.

22. The method of claim 4 in which said individual is suffering from common cold.

23. The method of claim 6 in which said individual is suffering from common cold.

24. The method of claim 7 in which said individual is suffering from common cold.

25. The method of claim 3 in which at least one of said symptoms is attributable, at least in part, to a common cold.

26. The method of claim 4 in which at least one of said symptoms is attributable, at least in part, to a common cold.

27. The method of claim 6 in which at least one of said symptoms is attributable, at least in part, to a common cold.

28. The method of claim 7 in which at least one of said symptoms is attributable, at least in part, to a common cold.

29. The method according to claim 9 wherein at least one flavonoid is troxerutin.

30. The method according to claim 13 wherein at least one flavonoid is troxerutin.

18. A method of treating rhinitis or hay fever which comprises administering to an individual in need thereof a therapeutically effective dosage of a pharmaceutically acceptable composition comprising at least one flavonoid which is a hydroxyethylrutoside, or a salt thereof.

19. A method of treating common cold which comprises administering to an individual in need thereof a therapeutically effective dosage of a pharmaceutically acceptable composition comprising at least one flavonoid which is a hydroxyethylrutoside, or a salt thereof.