Blends of poly(ester amide) polymers
First Claim
1. A poly(ester amide) (PEA) polymer blend having a glass transition temperature (Tg) above the Tg of poly(ester amide benzyl ester) (PEA-Bz) or poly {[N,N′
- -sebacoyl-bis-(L-leucine)-1,6-hexylene diester]-[N,N′
-sebacoyl-L-lysine 2,2,6,6-tetramethyl-4-amino-1-piperidinyloxyl amide]} (PEA-TEMPO), comprising;
a first PEA polymer having a Tg equal to or below the Tg of PEA-Bz or Tg of PEA-TEMPO, anda second PEA polymer having a Tg above the Tg of PEA-Bz or Tg of PEA-TEMPO, the PEA polymer blend comprising a PEA polymer of any of formulae 3–
7;
-[-sebacinate-L-Leu-hexanediol-L-Leu-]n-
Formula 3
-[-adipate-L-Leu-hexanediol-L-Leu-]n-
Formula 4A
-[-sebacinate-L-Leu-butanediol-L-Leu-]n-
Formula 4B
-[-adipate-L-Leu-butanediol-L-Leu-]n-
Formula 4C
-[-sebacinate-L-Val-hexanediol-L-Val-]n-
Formula 5A
-[-sebacinate-L-Phe-hexanediol-L-Phe-]n-
Formula 5B
-[-adipate-L-Val-butanediol-L-Val-]n-
Formula 5C
-[-adipate-L-Phe-butanediol-L-Phe-]n-
Formula 5D
-[-adipate-L-Leu-hexanediol-L-Leu-]m-[-adipate-Lys-R]n-R=benzyl ester or TEMPO
Formula 6A
-[-sebacinate-L-Leu-butanediol-L-Leu-]m-[-sebacinate-Lys-R]n-R=benzyl ester or TEMPO
Formula 6B
-[-adipate-L-Leu-butanediol-L-Leu-]m-[-adipate-Lys-R]n-R=benzyl ester or TEMPO
Formula 6C
-[-sebacinate-L-Val-hexanediol-L-Val-]m-[-sebacinate-Lys-R]n-R=benzyl ester or TEMPO
Formula 6D
-[-sebacinate-L-Phe-hexanediol-L-Phe-]m-[sebacinate-Lys-R]n-R=benzyl ester or TEMPO
Formula 6E
-[-adipate-L-Val-butanediol-L-Val-]m-[-adipate-Lys-R]n-R=benzyl ester or TEMPO
Formula 6F
-[-adipate-L-Phe-butanediol-L-Phe-]m-[-adipate-Lys-R]n-R=benzyl ester or TEMPO
Formula 6G
-[-sebacinate-L-Leu-hexanediol-L-Leu-]m-[-sebacinate-Lys R]n-R=methyl, ethyl, or propyl
Formula 7,
wherein m and n are independent positive integers ranging from 1 to 100,000.
1 Assignment
0 Petitions
Accused Products
Abstract
Provided herein is a poly(ester amide) (PEA) polymer blend and a polymeric coating containing the PEA polymer blend. The PEA polymer blend has a Tg above the Tg of poly(ester amide benzyl ester) (PEA-Bz) or the Tg of poly(ester amide TEMPO). The PEA polymer blend can form a coating on an implantable device, one example of which is a stent. The coating can optionally include a biobeneficial material and/or optionally with a bioactive agent. The implantable device can be used to treat or prevent a disorder such as one of atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
390 Citations
7 Claims
-
1. A poly(ester amide) (PEA) polymer blend having a glass transition temperature (Tg) above the Tg of poly(ester amide benzyl ester) (PEA-Bz) or poly {[N,N′
- -sebacoyl-bis-(L-leucine)-1,6-hexylene diester]-[N,N′
-sebacoyl-L-lysine 2,2,6,6-tetramethyl-4-amino-1-piperidinyloxyl amide]} (PEA-TEMPO), comprising;a first PEA polymer having a Tg equal to or below the Tg of PEA-Bz or Tg of PEA-TEMPO, and a second PEA polymer having a Tg above the Tg of PEA-Bz or Tg of PEA-TEMPO, the PEA polymer blend comprising a PEA polymer of any of formulae 3–
7;
-[-sebacinate-L-Leu-hexanediol-L-Leu-]n-
Formula 3
-[-adipate-L-Leu-hexanediol-L-Leu-]n-
Formula 4A
-[-sebacinate-L-Leu-butanediol-L-Leu-]n-
Formula 4B
-[-adipate-L-Leu-butanediol-L-Leu-]n-
Formula 4C
-[-sebacinate-L-Val-hexanediol-L-Val-]n-
Formula 5A
-[-sebacinate-L-Phe-hexanediol-L-Phe-]n-
Formula 5B
-[-adipate-L-Val-butanediol-L-Val-]n-
Formula 5C
-[-adipate-L-Phe-butanediol-L-Phe-]n-
Formula 5D
-[-adipate-L-Leu-hexanediol-L-Leu-]m-[-adipate-Lys-R]n-R=benzyl ester or TEMPO
Formula 6A
-[-sebacinate-L-Leu-butanediol-L-Leu-]m-[-sebacinate-Lys-R]n-R=benzyl ester or TEMPO
Formula 6B
-[-adipate-L-Leu-butanediol-L-Leu-]m-[-adipate-Lys-R]n-R=benzyl ester or TEMPO
Formula 6C
-[-sebacinate-L-Val-hexanediol-L-Val-]m-[-sebacinate-Lys-R]n-R=benzyl ester or TEMPO
Formula 6D
-[-sebacinate-L-Phe-hexanediol-L-Phe-]m-[sebacinate-Lys-R]n-R=benzyl ester or TEMPO
Formula 6E
-[-adipate-L-Val-butanediol-L-Val-]m-[-adipate-Lys-R]n-R=benzyl ester or TEMPO
Formula 6F
-[-adipate-L-Phe-butanediol-L-Phe-]m-[-adipate-Lys-R]n-R=benzyl ester or TEMPO
Formula 6G
-[-sebacinate-L-Leu-hexanediol-L-Leu-]m-[-sebacinate-Lys R]n-R=methyl, ethyl, or propyl
Formula 7,
wherein m and n are independent positive integers ranging from 1 to 100,000. - View Dependent Claims (2)
- -sebacoyl-bis-(L-leucine)-1,6-hexylene diester]-[N,N′
-
3. A polymeric coating on an implantable device, comprising a poly(ester amide) (PEA) polymer blend having a glass transition temperature (Tg) above the Tg of poly(ester amide benzyl ester) (PEA-Bz) or poly{[N,N′
- -sebacoyl-bis-(L-leucine)-1,6-hexylene diester]-[N,N′
-sebacoyl-L-lysine 2,2,6,6-tetramethyl-4-amino-1-piperidinyloxyl amide]} (PEA-TEMPO), comprising;a first PEA polymer having a Tg equal to or below the Tg of PEA-Bz or Tg of PEA-TEMPO, and a second PEA polymer having a Tg above the Tg of PEA-Bz or Tg of PEA-TEMPO. - View Dependent Claims (4, 5, 6, 7)
- -sebacoyl-bis-(L-leucine)-1,6-hexylene diester]-[N,N′
Specification