Non-invasive measurement system and method for measuring the concentration of an optically-active substance
First Claim
1. An apparatus, comprising:
- a. a light source adapted to transmit light towards an object containing a solution of an optically-active substance;
b. a polarizer, positioned between said light source and said object;
c. a first image capturing device, positioned to receive a portion of light reflected from said object and adapted to create a measured image therefrom, said measured image defining measured light intensity data;
d. a processor; and
e. a database, said database comprising predetermined concentration data for said optically-active substance and predetermined light intensity data, wherein said processor is further configured to calculate a concentration of said optically-active substance based on a selected portion of said measured light intensity data, a selected portion of said predetermined concentration data, and a selected portion of said predetermined light intensity data;
wherein said predetermined concentration data comprises one or more known concentration values and said predetermined light intensity data comprises one or more predetermined calculation space ratios.
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Accused Products
Abstract
A method and system for non-invasively measuring the concentration of an optically-active substance in a subject are provided. The system includes a light source adapted to transmit light towards a subject or object having a concentration of an optically-active substance, a polarizer positioned between the light source and the subject, an image capturing device, and a processor. The image capturing device is positioned to receive light reflected from the subject and create a measured image therefrom. The measured image defines measured light intensity data. The processor is configured to calculate a concentration of the optically-active substance based on a selected portion of the measured light intensity data.
41 Citations
109 Claims
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1. An apparatus, comprising:
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a. a light source adapted to transmit light towards an object containing a solution of an optically-active substance; b. a polarizer, positioned between said light source and said object; c. a first image capturing device, positioned to receive a portion of light reflected from said object and adapted to create a measured image therefrom, said measured image defining measured light intensity data; d. a processor; and e. a database, said database comprising predetermined concentration data for said optically-active substance and predetermined light intensity data, wherein said processor is further configured to calculate a concentration of said optically-active substance based on a selected portion of said measured light intensity data, a selected portion of said predetermined concentration data, and a selected portion of said predetermined light intensity data; wherein said predetermined concentration data comprises one or more known concentration values and said predetermined light intensity data comprises one or more predetermined calculation space ratios. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55)
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56. A method of calculating a concentration of an optically-active substance in an object containing a solution of said optically-active substance, the method comprising the steps of:
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a. providing at least one measured image of said object, each said measured image defining an array of measured intensities of light reflected from said object; b. calculating at least one ratio of measured light intensities from said array of measured intensities of light reflected from said object; c. calculating a concentration of said optically-active substance based on said at least one ratio of measured intensities, wherein calculating said concentration of said optically-active substance based on said at least one ratio of measured intensities comprises;
(1) defining a plurality of calculation spaces in said measured image, each said calculation space defining a plurality of measured intensities of light; and
(2) calculating a calculation space ratio in each said calculation space, wherein said at least one ratio of measured light intensities comprises at least one of said calculation space ratios; andd. displaying said calculated concentration. - View Dependent Claims (57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76)
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77. A method of calculating a concentration of an optically-active substance in an object containing a solution of said optically-active substance, the method comprising:
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a. providing a measured image of said object, said measured image defining an array of measured intensities of light reflected from said object; b. rotating said measured image to a plurality of rotational positions, wherein said plurality of rotational positions comprises 60 rotational positions, thereby generating a plurality of rotated measured intensities of light reflected from said object; c. calculating a concentration of said optically-active substance based on said measured intensities of light reflected from said object and said rotated measured intensities of light reflected from said object; and d. displaying said calculated concentration. - View Dependent Claims (78, 79, 80)
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81. A method of calculating a concentration of an optically-active substance in an object containing a solution of said optically-active substance, said object including a plurality of object regions, the method comprising:
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a. providing a plurality of measured intensity values of light reflected from said object, each said measured intensity value corresponding to one of said object regions; b. providing a plurality of predetermined intensities of light reflected from a reference object containing a solution of said optically-active substance, said reference object including a plurality of reference object regions, and each said predetermined intensity of light corresponding to one of said reference object regions and to a known concentration of said optically-active substance; c. selecting a portion of said plurality of predetermined intensities of light reflected from a reference object based on one or more statistical confidence parameters; d. calculating a concentration of said optically-active substance in said object based on one or more of said measured intensities of light reflected from said object and said selected portion of said plurality of predetermined intensities of light reflected from a reference object; and e. displaying said calculated concentration. - View Dependent Claims (82, 83, 84, 85)
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86. A method of calculating the concentration of an optically-active substance in an object containing a solution of said substance, the method comprising:
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a. providing a measured image of said object, said measured image defining measured light intensity data; b. providing a plurality of predetermined images of a reference object containing a solution of said optically-active substance, each said predetermined image corresponding to a known concentration of said optically-active substance, said plurality of predetermined images defining an array of predetermined light intensity data, said array of predetermined light intensity data further defining a plurality of subarrays of predetermined light intensity data; c. rotating said measured image to a plurality of rotational positions, thereby generating rotated light intensity data; d. selecting one of said subarrays of predetermined light intensity data; e. calculating the concentration of said optically-active substance in said object based on said measured light intensity data, said rotated light intensity data and said selected subarray of predetermined light intensity data; and f. displaying said calculated concentration. - View Dependent Claims (87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104)
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105. A computer readable medium comprising instructions for calculating the concentration of an optically-active substance in an object containing a solution of said substance, the instructions comprising:
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a. receiving a measured image of said object, said measured image defining measured light intensity data; b. receiving a plurality of predetermined images of a reference object containing a solution of said optically-active substance, each said predetermined image corresponding to a known concentration of said optically-active substance, said plurality of predetermined images defining an array of predetermined light intensity data, said array of predetermined light intensity data further defining a plurality of subarrays of predetermined light intensity data; c. rotating said measured image to a plurality of rotational positions, thereby generating rotated light intensity data; d. selecting one of said subarrays of predetermined light intensity data; and e. calculating the concentration of said optically-active substance in said object based on said measured light intensity data, said rotated light intensity data and said selected subarray of predetermined light intensity data.
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106. An apparatus for calculating the concentration of an optically-active substance based on light reflected from an object containing a solution of said substance, the apparatus comprising:
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a. a memory comprising predetermined concentration data and predetermined light intensity data; b. means for capturing measured light intensity data for light reflected from said object; and c. means for calculating a concentration of said optically-active substance based on said measured light intensity data, said predetermined concentration data and said predetermined light intensity data. - View Dependent Claims (107, 108, 109)
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Specification