Method of using a fully implantable miniature neurostimulator for vagus nerve stimulation

• US 7,167,751 B1
• Filed: 11/19/2004
• Issued: 01/23/2007
• Est. Priority Date: 03/01/2001
• Status: Expired due to Term

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Advanced Bionics Corporation (Sonova Holding AG)
• Inventors: Whitehurst, Todd K, McGivern, James P
• Primary Examiner(s): Bockelman; Mark
• Application Number:
  US10/993,989
• Time in Patent Office: 795 Days
• Field of Search: 607/1, 607/46, 607/116, 607/45, 607/118, 607/40, 607/41
• US Class Current: 607/40
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula

Abstract

A method of using a small implantable stimulator(s) with at least two electrodes small enough to have the electrodes located adjacent to the vagus nerve. The small stimulator provides a means of stimulating the vagus nerve when desired, and may be implanted via a minimal surgical procedure.

Claims

1. A method for treating a patient with an endocrine disorder, comprising:

generating stimulation pulses with an implanted stimulator in accordance with one or more stimulation parameters, the stimulator being coupled to at least two implanted electrodes; and

delivering the stimulation pulses via the at least two electrodes to at least one or more of an anterior superior pancreaticoduodenal plexus, an anterior inferior pancreaticoduodenal plexus, a posterior pancreaticoduodenal plexus, and an inferior pancreaticoduodenal plexus;

wherein the stimulation pulses are configured to treat the endocrine disorder.

2. The method of claim 1, further comprising:

providing a sensor;

using the sensor to sense a physical condition; and

using the sensed condition to determine the stimulation parameters.

3. The method of claim 2 wherein the sensor senses at least one of electrical activity of the brain, electrical activity of a nerve, muscle activity, limb tremor, head tremor, and patient movement.

4. The method of claim 2 wherein the sensor senses at least one of medication level, neurotransmitter level, hormone level, cytokine level, enzyme level, level of a bloodborne substance, and level of a substance in the cerebrospinal fluid.

5. The method of claim 2, wherein the sensor comprises at least one or more of a chemically sensitive field-effect transistor.

6. The method of claim 2, wherein one or more of the electrodes are configured to serve as the sensor.

7. The method of claim 2, further comprising communicating data representing the sensed physical condition to the stimulator.

8. The method of claim 2, further comprising determining the stimulation parameters based on the sensed condition in a closed loop manner.

9. The method of claim 1 wherein the stimulation parameters are determined using at least one external appliance.

10. The method of claim 1, further comprising providing power to the stimulator with at least one external appliance.

11. The method of claim 10 wherein providing power to the at least one stimulator further comprises storing the power received from the at least one external appliance.

12. The method of claim 1 further comprising providing and implanting more than one stimulator.

13. The method of claim 1 wherein the stimulation pulses are delivered at less than 100 Hz.

14. The method of claim 1 wherein the stimulation pulses are configured to relieve symptoms of the endocrine disorder.

15. The method of claim 1 wherein the stimulation pulses are delivered at a frequency that is greater than 100 Hz.

16. The method of claim 1, wherein the at least two electrodes are disposed on a surface of the stimulator.

17. The method of claim 1, wherein the stimulator comprises multiple stimulators.

18. The method of claim 17, wherein the multiple stimulators comprise at least a first stimulator and a second stimulator, and wherein the method further comprises:

sensing a physical condition related to the endocrine disorder with the first stimulator; and

generating with the second stimulator the stimulation pulses in accordance with the sensed physical condition.

19. The method of claim 1, further comprising implanting the stimulator no more than about 150 millimeters from at least one or more of the anterior superior pancreaticoduodenal plexus, the anterior inferior pancreaticoduodenal plexus, the posterior pancreaticoduodenal plexus, and the inferior pancreaticoduodenal plexus.