Apparatus and methods of optimal placement of deep brain stimulator
First Claim
1. A method for optical placement of a deep brain stimulator in a targated region of a brain of a living subject, comprising the steps of nonmanually selecting an initial optimal position from which a final position for optimal placement of a deep brain stimulator in the targrted region is determinated, wherein the step of nonmanually selecting the initial optimal position comprises the steps of:
- a. choosing an image volume as a common volume of reference from a set of image volumes, the set of image volumes having N image volumes each being acquired pre-operatively from a brain of a living subject having a deep brain stimulator placed in a target, N being an integer greater than 2;
b. registering each of the remaining N−
1 image volumes to the chosen common volume of reference by a nonrigid registration algorithm so as to create an atlas;
c. mapping spatial coordinates of the deep brain stimulator in each of the remaining N−
1 image volumes onto atlas coordinates in the atlas by a transformation that registers the corresponding image volume to the atlas;
d. computing a centroid of all the mapped atlas coordinates as an optimal target position of the deep brain stimulator in the atlas; and
e. projecting the optimal target position of the deep brain stimulator in the atlas onto the pre-operatively acquired image volume by an inverse of the transformation that registers the pre-operatively acquired image volume to the atlas so as to identify the initial optimal position of the deep brain stimulator in the targeted region of the brain of the living subject.
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Abstract
A method of optimal placement of a deep brain stimulator in a targeted region of a brain of a living subject for optimal deep brain stimulation. In one embodiment, the method includes the steps of nonmanually selecting an initial optimal position from, refining the nonmanually selected initial optimal position to determine a final position, and placing the deep brain stimulator at the final position in the targeted region of the brain of the living subject.
212 Citations
24 Claims
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1. A method for optical placement of a deep brain stimulator in a targated region of a brain of a living subject, comprising the steps of nonmanually selecting an initial optimal position from which a final position for optimal placement of a deep brain stimulator in the targrted region is determinated, wherein the step of nonmanually selecting the initial optimal position comprises the steps of:
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a. choosing an image volume as a common volume of reference from a set of image volumes, the set of image volumes having N image volumes each being acquired pre-operatively from a brain of a living subject having a deep brain stimulator placed in a target, N being an integer greater than 2; b. registering each of the remaining N−
1 image volumes to the chosen common volume of reference by a nonrigid registration algorithm so as to create an atlas;c. mapping spatial coordinates of the deep brain stimulator in each of the remaining N−
1 image volumes onto atlas coordinates in the atlas by a transformation that registers the corresponding image volume to the atlas;d. computing a centroid of all the mapped atlas coordinates as an optimal target position of the deep brain stimulator in the atlas; and e. projecting the optimal target position of the deep brain stimulator in the atlas onto the pre-operatively acquired image volume by an inverse of the transformation that registers the pre-operatively acquired image volume to the atlas so as to identify the initial optimal position of the deep brain stimulator in the targeted region of the brain of the living subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for optical placement of a deep brain stimulator in a targated region of a brain of a living subject, comprising the steps of:
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i. nonmanually selecting an initial optimal position in the targeted region; ii. finding a final position from the nonmanually selected initial optimal position; and iii. placing the deep brain simulator at the final position; wherein the step of nonmanually selecting the initial optimal position comprises the steps of; a. choosing an image volume as a common volume of reference from a set of image volumes, the set of image volumes having N image volumes each being acquired pre-operatively from a brain of a living subject having a deep brain stimulator placed in a target, N being an integer greater than 2; b. registering each of the remaining N−
1 image volumes to the chosen common volume of reference by a nonrigid registration algorithm so as to create an atlas;c. mapping spatial coordinates of the deep brain stimulator in each of the remaining N−
1 image volumes onto atlas coordinates in the atlas by a transformation that registers the corresponding image volume to the atlas;d. computing a centroid of all the mapped atlas coordinates as an optimal target position of the deep brain stimulator in the atlas; and e. projecting the optimal target position of the deep brain stimulator in the atlas onto the pre-operatively acquired image volume by an inverse of the transformation that registers the pre-operatively acquired image volume to the atlas so as to identify the initial optimal position of the deep brain stimulator in the targeted region of the brain of the living subject. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. An apparatus of optical placement of a deep brain simulator in a targeted region of a brain of a living subject, comprising a controller performing the step of nonmanually selecting an initial optimal position from which a final position for optical placement of deep brain simulator in the targeted region is determinated, wherein the controler furter performing the steps of:
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a. choosing an image volume as a common volume of reference from a set of image volumes, the set of image volumes having N image volumes each being acquired pre-operatively from a brain of a living subject having a deep brain stimulator placed in a target, N being an integer greater than 2; b. registering each of the remaining N−
1 image volumes to the chosen common volume of reference by a nonrigid registration algorithm so as to create an atlas;c. mapping spatial coordinates of the deep brain stimulator in each of the remaining N−
1 image volumes onto atlas coordinates in the atlas by a transformation that registers the corresponding image volume to the atlas;d. computing a centroid of all the mapped atlas coordinates as an optimal target position of the deep brain stimulator in the atlas; and e. projecting the optimal target position of the deep brain stimulator in the atlas onto the pre-operatively acquired image volume by an inverse of the transformation that registers the pre-operatively acquired image volume to the atlas so as to identify the initial optimal position of the deep brain stimulator in the targeted region of the brain of the living subject. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24)
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Specification