Aerosol metering valve

• US 7,168,597 B1
• Filed: 02/23/2000
• Issued: 01/30/2007
• Est. Priority Date: 03/12/1999
• Status: Expired due to Term

• Current Assignee: GlaxoSmithKline LLC (GlaxoSmithKline PLC)
• Original Assignee: Smithkline Beecham Corporation (Smithkline Beecham PLC)
• Inventors: Anderson, Gregor John McLennan, Rand, Paul Kenneth, Jones, Anthony Patrick
• Primary Examiner(s): Mancene; Gene
• Assistant Examiner(s): SHAVER, KEVIN P
• Application Number:
  US09/936,505
• Time in Patent Office: 2,533 Days
• Field of Search: 222/402.2, 222/402.24, 222/406, 222/407, 222/425, 222/434, 222/450, 251/65, 128/200.23, 604/186, 604/407
• US Class Current: 222/402.2
• CPC Class Codes: A61M 15/0006 using rotating means
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/0066 with means for varying the dose size
• CPC Class Codes: A61M 15/0071 having a display or indicator
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 2205/0266 Shape memory materials
• CPC Class Codes: A61P 11/08 Bronchodilators
• CPC Class Codes: A61P 11/14 Antitussive agents
• CPC Class Codes: A61P 13/00 Drugs for disorders of the urinary system
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/00 Drugs for disorders of the endocrine system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: B65D 83/54 Metering valves ; Metering valve assemblies

Abstract

A metering valve that includes a valve body defining a metering chamber having an inlet valve adapted to be reversibly actuable from an open position to a closed position located at the inlet, and an outlet valve adapted to be reversibly actuable from a dispensing to a non-dispensing position located at the outlet, where the outlet valve includes an outlet valve seat adapted to be in biasable contact with an outlet valve poppet is described. Aerosol containers and inhalation devices that include such metering valves are also described, as are methods of using such inhalation devices.

Claims

1. A metering valve comprising:

a valve body defining a metering chamber having an inlet and an outlet;

an inlet valve adapted to be reversibly actuable from an open to a closed position located at the inlet;

an outlet valve adapted to be reversibly actuable from a dispensing to a non-dispensing position located at the outlet, wherein said outlet valve includes an outlet valve seat adapted to be in biasable contact with an outlet valve poppet; and

a magnetic actuating mechanism which is actuable to move the outlet valve poppet out of contact with the outlet valve seat.

2. The metering valve according to claim 1, wherein said inlet valve includes an inlet valve seat adapted to be in biasable contact with an inlet valve poppet.

3. The metering valve according to claim 2, wherein the inlet and/or outlet valve poppet includes an incompressible material, and wherein the inlet and/or outlet valve seat includes a compressible material.

4. The metering valve according to claim 2, wherein the inlet and/or outlet valve poppet includes a compressible material, and wherein the inlet and/or outlet valve seat includes an incompressible material.

5. The metering valve according to claim 2, wherein the inlet valve poppet is in the form of a ball, a mushroom, a cone, a disc or a plug.

6. An aerosol container comprising a metering valve according to claim 5.

7. The metering valve according to claim 2, wherein the magnetic actuating mechanism is further actuable to move the inlet valve poppet out of contact with the inlet valve seat.

8. The metering valve according to claim 7, wherein the magnetic actuating mechanism comprises a magnetically actuable inlet mover adapted to move the inlet valve poppet out of contact with the inlet valve seat.

9. An aerosol container comprising a metering valve according to claim 8.

10. The metering valve according to claim 7, wherein the magnetically actuable inlet valve mover includes a magnetic material or a magnetically inductive material.

11. An aerosol container comprising a metering valve according to claim 10.

12. The metering valve according to claim 7, wherein the inlet valve mover moves the inlet valve poppet out of contact with the inlet valve seat upon movement of the inlet valve mover from a first position to a second position, and wherein the magnetic actuating mechanism has an actuator element which is adapted to magnetically interact with the inlet valve mover to move it between the first and second positions.

13. An aerosol container comprising a metering valve according to claim 12.

14. The metering valve according to claim 7, wherein the magnetic actuating mechanism on actuation thereof magnetically interacts with the inlet valve poppet to cause said movement thereof.

15. An aerosol container comprising a metering valve according to claim 14.

16. The metering valve according to claim 7, wherein the magnetic actuating mechanism has a magnet element which is movable from a first position, in which the magnet element magnetically interacts with the outlet valve poppet to move the outlet valve poppet off the outlet valve seat, to a second position, in which the magnet element magnetically interacts with the inlet valve poppet to move the inlet valve poppet off the inlet valve seat.

17. The metering valve according to claim 16 constructed and arranged such that when the outlet valve poppet is out of contact with the outlet valve seat, the inlet valve poppet is always in contact with the inlet valve seat.

18. An aerosol container comprising a metering valve according to claim 17.

19. An aerosol container comprising a metering valve according to claim 16.

20. The metering valve according to claim 7 constructed and arranged such that when the outlet valve poppet is out of contact with the outlet valve seat, the inlet valve poppet is always in contact with the inlet valve seat.

21. An aerosol container comprising a metering valve according to claim 20.

22. An aerosol container comprising a metering valve according to claim 7.

23. An aerosol container comprising a metering valve according to claim 2.

24. The metering valve according to claim 1, wherein the inlet valve is in the closed position and the outlet valve is in the non-dispensing position when the metering valve is at rest.

25. The metering valve according to claim 1, wherein the inlet valve and the outlet valve are adapted to be independently operable.

26. The metering valve according to claim 1, wherein the outlet valve poppet is in the form of a ball, a mushroom, a cone, a disc or a plug.

27. An aerosol container comprising a metering valve according to claim 26.

28. The metering valve according to claim 1, wherein said valve body additionally defines a sampling chamber, and wherein the inlet is adapted to permit flow from the sampling chamber to the metering chamber.

29. The metering valve according to claim 28, wherein the metering chamber is adapted to have a fixed volume.

30. An aerosol container comprising a metering valve according to claim 29.

31. The metering valve according to claim 28, wherein the metering chamber is adapted to have a variable metering volume.

32. An aerosol container comprising a metering valve according to claim 31.

33. An aerosol container comprising a metering valve according to claim 28.

34. The metering valve according to claim 1, wherein the magnetic actuating mechanism comprises a magnetically actuable outlet mover adapted to move the outlet valve poppet out of contact with the outlet valve seat.

35. The metering valve according to claim 34, wherein the magnetically actuable outlet valve mover includes a magnetic material or a magnetically inductive material.

36. An aerosol container comprising a metering valve according to claim 35.

37. The metering valve according to claim 34, wherein the outlet valve mover moves the outlet valve poppet out of contact with the outlet valve seat upon movement of the outlet valve mover from a first position to a second position, and wherein the magnetic actuating mechanism has an actuator element which is adapted to magnetically interact with the outlet valve mover to move it between the first and second positions.

38. An aerosol container comprising a metering valve according to claim 37.

39. An aerosol container comprising a metering valve according to claim 24.

40. The metering valve according to claim 1, wherein the magnetic actuating mechanism on actuation thereof magnetically interacts with the outlet valve poppet to cause said movement thereof.

41. An aerosol container comprising a metering valve according to claim 40.

42. An aerosol container comprising a metering valve according to claim 1.

43. An aerosol container according to claim 42, wherein the valve body of the metering valve is not movable relative to the container.

44. An aerosol container according to claim 42, wherein the container contains a suspension of a medicament in a propellant.

45. An aerosol container according to claim 44, wherein said propellant comprises liquefied HFA-134a, HFA-227, or carbon dioxide.

46. An aerosol container according to claim 44, wherein the medicament is selected from the group consisting of albuterol, salmeterol, fluticasone propionate, beclomethasone dipropionate, salts or solvates thereof and any mixtures thereof.

47. An aerosol container according to claim 42, wherein the container contains a compressed gas.

48. An aerosol container according to claim 47, wherein the container contains compressed air.

49. An inhalation device for dispensing medicament to a patient comprising:

a housing;

an aerosol container, locatable within said housing, said aerosol container comprising a metering valve that comprises

a valve body defining a metering chamber having an inlet and an outlet;

an inlet valve adapted to be reversibly actuable from an open to a closed position located at the inlet;

an outlet valve adapted to be reversibly actuable from a dispensing to a non-dispensing position located at the outlet, wherein said outlet valve includes an outlet valve seat adapted to be in biasable contact with an outlet valve poppet; and

a magnetic actuating mechanism which is actuable to move the outlet valve poppet out of contact with the outlet valve seat; and

an outlet valve trigger for triggering the movement of the outlet valve poppet out of contact with the outlet valve seat.

50. An inhalation device according to claim 49, wherein the outlet valve trigger is triggerable in response to the breath of a patient.

51. An inhalation device according to claim 50, wherein the outlet valve trigger is triggerable in response to the inward breath of a patient.

52. An inhalation device according to claim 50, wherein the outlet valve trigger is triggerable at a trigger point which is coupled to the end of the exhalation part of a patient'"'"'s breath cycle.

53. An inhalation device according to claim 50, wherein the outlet valve trigger communicates with a sensor which senses the breath of a patient.

54. An inhalation device according to claim 53, wherein said sensor comprises a breath-movable element which is movable in response to the breath of a patient.

55. An inhalation device according to claim 54, wherein said breath-movable element is selected from the group consisting of a vane, a sail, a piston and an impeller.

56. An inhalation device according to claim 53, wherein said sensor comprises a pressure sensor for sensing the pressure profile associated with the breath of a patient.

57. An inhalation device according to claim 53, wherein said sensor comprises an airflow sensor for sensing the airflow profile associated with the breath of a patient.

58. An inhalation device according to claim 53, wherein said sensor comprises a temperature sensor for sensing the temperature profile associated with the breath of a patient.

59. An inhalation device according to claim 53, wherein said sensor comprises a moisture sensor for sensing the moisture profile associated with the breath of a patient.

60. An inhalation device according to claim 53, wherein said sensor comprises a gas sensor for sensing the oxygen or carbon dioxide profile associated with the breath of a patient.

61. An inhalation device according to claim 53, wherein said sensor comprises a piezoelectric or piezoresistive element.

62. An inhalation device according to claim 49, wherein the inlet valve further comprises an inlet valve seat and an inlet valve poppet in biasable contact therewith.

63. An inhalation device according to claim 62, further comprising an inlet valve trigger for triggering the movement of the inlet valve poppet out of contact with the inlet valve seat.

64. An inhalation device according to claim 63, wherein the outlet valve trigger and the inlet valve triggers are both magnetic triggers.

65. An inhalation device according to claim 64, wherein the outlet valve trigger interacts magnetically with an outlet shuttle contacting the outlet valve poppet and/or the inlet valve trigger interacts magnetically with an inlet shuttle contacting the inlet valve poppet.

66. An inhalation device according to claim 65, wherein the outlet shuttle comprises a magnetic material.

67. An inhalation device according to claim 65, wherein the outlet shuttle comprises a material which is magnetically inductive and the outlet valve trigger comprises an inductive element capable of inducing magnetism therein and/or the inlet shuttle comprises a material which is magnetically inductive and the inlet valve trigger comprises an inductive element capable of inducing magnetism therein.