Drug delivery device and method for bi-directional drug delivery
First Claim
1. A drug delivery device comprising:
- a medical device body having an exterior surface and an interior surface;
a plurality of openings in the device body;
a first therapeutic agent and a second therapeutic agent disposed in the openings and arranged to deliver the first therapeutic agent primarily to the exterior surface and to deliver the second therapeutic agent primarily to the interior surface; and
a bioerodible barrier layer disposed in the openings at a radially intermediate position with respect to said exterior surface and said interior surface of the medical device, and wherein said first therapeutic agent is provided at a radially exterior position with respect to the barrier layer and said second therapeutic agent is provided at a radially interior position with respect to the barrier layer.
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Accused Products
Abstract
A drug delivery device is provided with openings for directional delivery of a plurality of therapeutic agents to blood vessels or other lumens or organs. In particular, the invention relates to the delivery of different therapeutic agents, different quantities of therapeutic agents, or different release profiles of the same or different therapeutic agents in different directions from the drug delivery device. The invention is useful, for example, for delivering antirestenotic, antithrombotic, antiplatelet, antiproliferative, antineoplastic, immunosuppressive, angiogenic, anti-inflammatory, or antiangiogenic agents and/or vasodilators to a blood vessel. In one embodiment, antiproliferative, antineoplastic, angiogenic, antiangiogenic, anti-inflammatory, and/or antirestenotic agents are delivered to the wall of a blood vessel and antithrombotic agents, antiplatelet agents, and/or vasodilators are delivered to the lumen of a blood vessel.
240 Citations
20 Claims
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1. A drug delivery device comprising:
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a medical device body having an exterior surface and an interior surface; a plurality of openings in the device body; a first therapeutic agent and a second therapeutic agent disposed in the openings and arranged to deliver the first therapeutic agent primarily to the exterior surface and to deliver the second therapeutic agent primarily to the interior surface; and a bioerodible barrier layer disposed in the openings at a radially intermediate position with respect to said exterior surface and said interior surface of the medical device, and wherein said first therapeutic agent is provided at a radially exterior position with respect to the barrier layer and said second therapeutic agent is provided at a radially interior position with respect to the barrier layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A drug delivery device comprising:
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an exterior surface; an interior surface; a plurality of openings traversing said exterior surface and said interior surface, said openings having a barrier layer arranged at a radially intermediate position with respect to said exterior surface and said interior surface; at least one first therapeutic agent in a therapeutic layer disposed at a radially exterior position with respect to said barrier layer; and at least one second therapeutic agent in a therapeutic layer disposed at a radially interior position with respect to said barrier layer, wherein the barrier layer substantially prevents passage of the first and second therapeutic agents there through. - View Dependent Claims (12, 13, 14, 15, 16)
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17. A drug delivery device comprising:
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a medical device body having an exterior surface and an interior surface; a plurality of through openings in the device body traversing the exterior surface and the interior surface; an antirestenotic agent disposed in the openings and arranged to deliver the antirestenotic agent primarily to the exterior surface; an ADP receptor agonist disposed in the openings and arranged to deliver the ADP receptor agonist primarily to the interior surface; and a bioerodible barrier layer disposed at a radially intermediate position of the openings with respect to said exterior surface and said interior surface of the medical device, and wherein said first antirestenotic agent is provided at a radially exterior position with respect to the barrier layer and said ADP receptor agonist is provided at a radially interior position with respect to the barrier layer. - View Dependent Claims (18, 19, 20)
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Specification