Tumor suppressor CAR-1
First Claim
1. A method for suppressing growth of a cancer cell comprising directly contacting said cell with an expression cassette comprising a polynucleotide encoding a polypeptide having the sequence of SEQ ID NO:
- 1 or SEQ ID NO;
2, wherein said polynucleotide is under the control of a promoter operable in eukaryotic cells.
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Abstract
The present invention relates to a new tumor suppressor, designated CAR-1, the gene for which is located on the short arm of human chromosome 1. This gene is directly implicated in colon, kidney and breast cancers, and the CAR-1 ubiquitous expression of the corresponding transcript suggests that it may be involved in yet others. Thus, one aspect of the invention is the diagnosis of CAR-1-related malignancies. The full length cDNA for CAR-1, as well as oligonucleotides derived therefrom, are disclosed. Screening methods for modulators of CAR-1 function and expression, as well as methods for cancer therapy, are described.
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Citations
18 Claims
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1. A method for suppressing growth of a cancer cell comprising directly contacting said cell with an expression cassette comprising a polynucleotide encoding a polypeptide having the sequence of SEQ ID NO:
- 1 or SEQ ID NO;
2, wherein said polynucleotide is under the control of a promoter operable in eukaryotic cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- 1 or SEQ ID NO;
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10. A method for altering the phenotype of a tumor cell comprising the step of directly contacting the cell with a nucleic acid comprising (i) a region encoding a tumor suppressor designated CAR-1 having the sequence of SEQ ID NO:
- 1 or SEQ ID NO ;
2 and (ii) a promoter active in said tumor cell, wherein said promoter is operably linked to the region encoding said tumor suppressor, under conditions permitting the uptake of said nucleic acid by said tumor cell. - View Dependent Claims (11, 12, 13, 14, 15)
- 1 or SEQ ID NO ;
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16. A method for treating a subject with cancer comprising the step of directly administering to a cancer cell in said subject a nucleic acid comprising (i) a region encoding a tumor suppressor designated CAR-1 having the sequence of SEQ ID NO:
- 1 or SEQ ID NO;
2 and (ii) a promoter active in eukaryotic cells, wherein said promoter is operably linked to the region encoding said tumor suppressor. - View Dependent Claims (17, 18)
- 1 or SEQ ID NO;
Specification