Device for determining a glucose concentration in a tissue fluid

• US 7,169,600 B2
• Filed: 02/19/2004
• Issued: 01/30/2007
• Est. Priority Date: 07/28/1999
• Status: Expired due to Fees

• Current Assignee: Roche Diagnostics GmbH (Roche Holding AG)
• Original Assignee: Roche Diagnostics GmbH (Roche Holding AG)
• Inventors: Hoss, Udo, Gessler, Ralf, Pfleiderer, Hans-Joerg, Fussgaenger, Rolf, Zieten, Hans-Ulrich
• Primary Examiner(s): GITOMER, RALPH J
• Application Number:
  US10/782,290
• Publication Number:
  US 20040191848A1
• Time in Patent Office: 1,076 Days
• Field of Search: 435/14, 435/287.1, 204/409, 205/787
• US Class Current: 435/287.1
• CPC Class Codes: A61B 5/14528 invasively
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors

Abstract

The invention concerns an arrangement for determining the concentration of glucose in a tissue fluid. In the microdialysis technology used for this purpose, perfusate-containing glucose is transported in intermittent delivery pulses through a microdialysis probe inserted into the tissue fluid and dialysate obtained in this process is passed to a measuring cell to record the glucose content. In order to achieve an exact determination of glucose even with a reduced dialysis period, it is proposed that the starting content of glucose in the perfusate is adapted to the glucose content of the tissue fluid by means of a control device in accordance with a command variable derived from the measurement signals of the measuring cell. When the control deviation is negligible the momentary starting content of glucose in the perfusate can be determined as a measure for the glucose content of the tissue fluid.

Claims

1. A device for determining a glucose concentration in a tissue fluid, the device comprising

a microdialysis probe for a diffusion exchange of glucose with surrounding tissue fluid,

a perfusion device for perfusing the microdialysis probe with glucose-containing perfusate to obtain dialysate,

a dialysate glucose content measuring cell located downstream of the microdialysis probe, and

a control device, which adjusts the content of glucose in the perfusate upstream of the microdialysis probe to the glucose content of the tissue fluid in accordance with a command variable derived from measurement signals of the measuring cell.

2. The device of claim 1 further comprising an evaluation unit to determine a momentary starting content of glucose in the perfusate when a control deviation is negligible as a measure for the glucose content of the tissue fluid.

3. The device of claim 2 wherein the perfusion device has a perfusate store and a transport unit for an intermittent transport of perfusate.

4. The device of claim 2 wherein the control device has a flow mixer that includes a valve formed to adjust the starting content of the glucose in the perfusate.

5. The device of claim 2 wherein the control device has a digital controller.

6. The device of claim 1 wherein the perfusion device has a perfusate store and a transport unit for an intermittent transport of perfusate.

7. The device of claim 6 wherein the perfusate store has at least two separate reservoirs to hold perfusion liquids with different glucose concentrations.

8. The device of claim 6 wherein the perfusate store has a first reservoir containing a glucose-free perfusion liquid and a second reservoir containing a glucose-containing perfusion liquid.

9. The device of claim 6 wherein the control device has a flow mixer that includes a valve formed to adjust a starting content of the glucose in the perfusate.

10. The device of claim 9 wherein the control device has a digital controller.

11. The device of claim 1 wherein the control device has a flow mixer that includes a valve formed to adjust a starting content of the glucose in the perfusate.

12. The device of claim 11 wherein the valve is a mixing valve or a clock-pulsed directional control valve.

13. The device of claim 11 wherein the flow mixer includes an inlet side connected to reservoirs for feeding in perfusion fluids with different glucose concentrations and an outlet side connected to a perfusate tube leading to the microdialysis probe.

14. The device of claim 11 wherein the control device has a digital controller.

15. The device of claim 1 wherein the control device has a digital controller.

16. The device of claim 15 wherein the controller is a microcontroller.

17. A device for determining a glucose concentration in a tissue fluid, comprising

a microdialysis probe inserted into the tissue fluid,

at least two reservoirs for holding perfusion liquids with different glucose concentrations,

a transport unit to perfuse the microdialysis probe with glucose-containing perfusate to obtain dialysate,

a flow-through measuring cell located downstream of the microdialysis probe to register measurement signals that correlate with the glucose content of the dialysate, and

a control device connected on an input side to the measuring cell, which control device has a flow mixer connected on an inlet side to the reservoirs and on an outlet side to the microdialysis probe, which acts as an adjuster to regulate the content of glucose in the perfusate upstream of the microdialysis probe.

18. A device for determining the glucose concentration in a tissue fluid, comprising

a microdialysis probe,

a perfusion device in communication with the micro dialysis probe to perfuse the microdialysis probe with glucose-containing perfusate to obtain dialysate,

a measuring cell being located downstream of the microdialysis probe, and having an electrode sensor formed to detect measurement signals that correlate with the glucose content of the dialysate, and

a control device, which adjusts the content of glucose in the perfusate upstream of the microdialysis probe to the glucose content of the tissue fluid in accordance with a command variable corresponding with the glucose concentration of the tissue fluid and being derived from the measurement signals of measuring cell.

19. The device of claim 18 further comprising an evaluation unit to determine a momentary starting content of glucose in the perfusate.

20. The device of claim 18 wherein the perfusion device has a perfusate store and a transport unit.

21. The device of claim 20 wherein the perfusate store has at least two separate reservoirs to hold perfusion liquids with different glucose concentrations.

22. The device of claim 20 wherein the perfusate store has a first reservoir containing a glucose-free perfusion liquid and a second reservoir containing a glucose-containing perfusion liquid.

23. The device of claim 18 wherein the control device has a flow mixer comprising a mixing valve or clock-pulsed directional control valve as an adjuster formed to adjust starting content of glucose in the perfusate.

24. The device of claim 23 wherein an inlet side of the flow mixer is connected to at least two reservoirs for feeding in perfusion fluids with different glucose concentrations and an outlet side of the flow mixer connects a perfusate tube leading to the microdialysis probe.

25. The device of claim 18 wherein the control device has a digital controller.

26. A device for determining a glucose concentration in a tissue fluid, comprising

a microdialysis probe inserted into the tissue fluid,

at least two reservoirs for holding perfusion liquids with different glucose concentrations,

a transport unit in communication with the microdialysis probe and the at least two reservoirs, to perfuse the microdialysis probe with glucose-containing perfusate to obtain dialysate,

a flow-through measuring cell located downstream of the microdialysis probe and formed to register measurement signals that correlate with the glucose content of the dialysate, and

a control device in communication wit the measuring cell, the control device having a flow mixer in communication with at least two reservoirs and with the microdialysis probe to act as an adjuster to regulate the content of glucose in the perfusate upstream of the microdialysis probe.