Methods for preparing 7-(2′-substituted-β-D-ribofuranosyl)-4-(NR2R3)-5-(substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine derivatives
First Claim
Patent Images
1. A method for preparing 7-(2′
- -R1-substituted-β
-D-ribofuranosyl)-4-(NR2R3)-5-(ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine of formula I;
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Abstract
Disclosed are methods and intermediates for the preparation of 7-(2′-R1-substituted-β-D-ribofuranosyl)-4-amino-5-(optionally substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine compounds. These compounds are useful in treating viral infections caused by a flaviviridae family virus, such as hepatitis C virus. Such 7-(2′-substituted-β-D-ribofuranosyl)-4-amino-5-(optionally substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine compounds are represented by Formula I as follows:
wherein, each of R1, R2, and R3 are as defined herein.
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Citations
51 Claims
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1. A method for preparing 7-(2′
- -R1-substituted-β
-D-ribofuranosyl)-4-(NR2R3)-5-(ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine of formula I;
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- -R1-substituted-β
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11. A method for the synthesis of 7-(2′
- -R1-substituted-β
-D-ribofuranosyl)-4-(NR2R3)-5-(ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine of formula I;
- View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
- -R1-substituted-β
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21. A method for the synthesis of 7-(2′
- -R1-substituted-β
-D-ribofuranosyl)-4-(NR2R3)-5-(ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine of formula I;
- View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30)
- -R1-substituted-β
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31. A method for the synthesis of 7-(2′
- -R1-substituted-β
-D-ribofuranosyl)-4-(NR2R3)-5-(2-substituted ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine of formula II;
- View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
- -R1-substituted-β
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42. A method for the synthesis of 7-(2′
- -methyl-β
-D-ribofuranosyl)-4-amino-5-(ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine of formula III;
- View Dependent Claims (43)
- -methyl-β
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44. A method for the synthesis of 7-(2′
- -methyl-β
-D-ribofuranosyl)-4-amino-5-(ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine of formula III;
- View Dependent Claims (45)
- -methyl-β
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46. A method for the synthesis of 7-(2′
- -methyl-β
-D-ribofuranosyl)-4-amino-5-(ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine of formula III;
- View Dependent Claims (47)
- -methyl-β
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48. A compound of formula V:
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49. A compound selected from the group consisting of:
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4-chloro-5-(ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine; 4-chloro-5-(trimethylsilylethyn-1-yl)-pyrrolo[2,3-d]pyrimidine; and 4-chloro-5-(phenylethyn-1-yl)-pyrrolo[2,3-d]pyrimidine.
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50. A compound of formula VI:
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51. A compound selected from the group consisting of:
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4-amino-5-(ethyn-1-yl)-pyrrolo[2,3-d]pyrimidine; 4-amino-5-(trimethylsilylethyn-1-yl) -pyrrolo[12,3-d]pyrimidine; and 4-amino-5-(phenylethyn-1-yl)-pyrrolo[2,3-d]pyrimidine.
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Specification