MALDI-IM-ortho-TOF mass spectrometry with simultaneous positive and negative mode detection
First Claim
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1. A method of preparing an aerosolized sample for analysis by laser desorption mass spectrometry, comprising the steps of:
- combining the sample with a matrix comprising a native or derivatized fullerene; and
,producing aerosol particles from the combined sample and matrix.
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Abstract
An ion mobility/mass spectrometry method and instrument using aerosolized samples and dual positive and negative mode detection is described. Sample preparation methods are also described.
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Citations
55 Claims
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1. A method of preparing an aerosolized sample for analysis by laser desorption mass spectrometry, comprising the steps of:
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combining the sample with a matrix comprising a native or derivatized fullerene; and
,producing aerosol particles from the combined sample and matrix. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of preparing an aerosolized sample for analysis by laser desorption mass spectrometry, comprising the steps of:
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combining the sample with a matrix comprising a native or derivatized nanotube; and
,producing aerosol particles from the combined sample and matrix. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of preparing an aerosolized sample for analysis by laser desorption mass spectrometry, comprising the steps of:
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combining the sample with a matrix comprising a surface derivatized inorganic particle; and
,producing aerosol particles from the combined sample and matrix. - View Dependent Claims (22)
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23. A method of preparing an aerosolized sample for analysis by laser desorption mass spectrometry, comprising the steps of:
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combining the sample with a matrix comprising nanoparticulates; and
,producing aerosol particles from the combined sample and matrix.
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24. A method for the analysis of samples using ion mobility resolved mass spectrometric data comprising the steps of:
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introducing a sample comprising a liquid droplet or aerosol into a desorption source; ionizing and desorbing gaseous analyte species from said liquid droplet or aerosol; separating said analyte species from one another in an ion mobility cell; and
,resolving said analyte species in an orthogonal time-of-flight mass spectrometer. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33)
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34. An instrument for the collection of ion mobility resolved mass spectrometric data comprising:
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an aerosol formation apparatus to form an aerosol; a desorption ionization source coupled to said apparatus and capable of desorbing and ionizing species comprising the aerosol; two ion mobility cells fluidly coupled to said aerosol formation apparatus, each mobility cell comprising a drift tube having a separation axis configured 180°
to the separation axis of the drift tube of the other mobility cell; and
,at least one time-of-flight mass spectrometer fluidly coupled to said mobility cell and having a flight tube orthogonal to the axis of the drift tube of the mobility cell. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54)
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55. An apparatus for generating matrix particles for implantation into a sample for desorption/ionization comprising:
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a nanoparticle source; a charging device fluidly coupled to and receiving nanoparticles from said nanoparticle source and forming charged nanoparticles; a focusing lens fluidly coupled to the charging device to focus said charged nanoparticles, a particle accelerator fluidly coupled to said focusing lens; and
,a sample stage to position a sample and receive charged nanoparticles from said particle accelerator.
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Specification