Living body light measurement system and signal processing method

• US 7,171,250 B2
• Filed: 12/14/2004
• Issued: 01/30/2007
• Est. Priority Date: 02/26/2004
• Status: Expired due to Fees

• Current Assignee: Hitachi, Ltd.
• Original Assignee: Hitachi, Ltd.
• Inventors: Yamamoto, Tsuyoshi, Maki, Atsushi, Kawaguchi, Hideo, Katura, Takusige
• Primary Examiner(s): Winakur; Eric F.
• Assistant Examiner(s): Lin; Jack
• Application Number:
  US11/010,668
• Publication Number:
  US 20050192490A1
• Time in Patent Office: 777 Days
• Field of Search: 600/310, 600/322, 600/323, 600/340, 600/344
• US Class Current: 600/310
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 5/0042 for the brain
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue

Abstract

An image generating methodology for displaying brain activation areas with improved accuracy in a living body light measurement system for generating an image of the changes in blood volume of the brain. A spatial intensity distribution of changes in blood volume can be generated by detecting brain activation in many sampling points, and a spatial interpolation process is executed on this data. A threshold process is executed on the distribution to extract the distribution of coordinates having a signal intensity of at least the predetermined threshold. The displacement between the brain activation area and the maximal location of the distribution is stored in a recording unit of the system in order to compensate for the distribution extracted by the threshold process. Accordingly, brain activation areas can be estimated with greater location accuracy, and the diagnosis and medial treatment for brain diseases can likewise be executed with greater accuracy.

Claims

1. A living body light measurement system, comprising:

a plurality of light sources for illuminating a subject with light;

a plurality of light detectors for detecting the light illuminated from said plurality of light sources after said light is propagated through the subject;

a first arithmetic unit for generating a first signal intensity distribution for said subject based on the light signal detected with said plurality of light detectors;

a second arithmetic unit for executing a threshold process to generate a second signal intensity distribution for signal intensities which are at least equal to a predetermined threshold for signal intensity distribution;

a recording unit for storing data which defines a displacement between a brain activation area and a maximal location of the signal intensity distribution which is generated when said first arithmetic unit generates the first signal intensity distribution, wherein location information for said plurality of light sources and plurality of light detectors is obtained before said first signal intensity distribution is generated; and

a third arithmetic unit for generating a third signal intensity distribution which utilizes the data stored in the recording unit to compensate for the displacement for the threshold-processed second signal intensity distribution.

2. The living body light measurement system according to claim 1, further comprising:

a display unit for displaying the third signal intensity distribution.

3. The living body light measurement system according to claim 1, further comprising:

a setting unit for setting said threshold.

4. The living body light measurement system according to claim 1, wherein said plurality of light sources and said plurality of light detectors are alternately located in the form of a lattice.

5. The living body light measurement system according to claim 1, further comprising:

a setting unit for selecting whether to display the third signal intensity distribution or the second signal intensity distribution.

6. A living body light measurement system comprising:

a plurality of light sources for illuminating a subject with light;

a plurality of light detectors for detecting the light illuminated from said plurality of light sources after said light is propagated through the subject;

a first arithmetic unit for generating a first signal intensity distribution for said subject based on the light signal detected with said plurality of light detectors;

a second arithmetic unit for executing a threshold process to generate a second signal intensity distribution for signal intensities which are at least equal to a predetermined threshold for signal intensity distribution;

a recording unit for storing data which defines a displacement between a brain activation area and a maximal location of the signal intensity distribution which is generated when said first arithmetic unit generates the first signal intensity distribution; and

a third arithmetic unit for generating a third signal intensity distribution which utilizes the data stored in the recording unit to compensate for the displacement for the threshold-processed second signal intensity distribution.

7. The living body light measurement system according to claim 6, further comprising:

a display unit for displaying the third signal intensity distribution.

8. The living body light measurement system according to claim 6, further comprising:

a setting unit for setting said threshold.

9. The living body light measurement system according to claim 6, wherein said plurality of light sources and said plurality of light detectors are alternately located in the form of a lattice.

10. The living body light measurement system according to claim 6, further comprising:

a setting unit for selecting whether to display the third signal intensity distribution or the second signal intensity distribution.

11. A signal processing method, utilized for a living body light measurement system for measuring an inside of a subject by illuminating light to a plurality of areas of the subject and detecting the light propagated through the inside of the subject, said method comprising the steps of:

generating data, from a computer simulation, of the displacement between a brain activation area and a maximal location of signal intensity distribution on the subject generated on the basis of the light signal detected at said plurality of areas;

illuminating the light to said plurality of areas of the subject;

detecting the light illuminated to the subject and propagated through the inside of the subject;

generating a first signal intensity distribution of the subject on the basis of the detected light;

executing a threshold process to generate a second signal intensity distribution of intensities which are at least equal to a predetermined threshold; and

compensating for a displacement based on the data generated from the computer simulation and creating a third threshold-processed signal intensity distribution.

12. The signal processing method according to claim 11, further comprising a step of:

displaying the third signal intensity distribution.

13. The signal processing method according to claim 11, wherein the threshold is a variable value which can be set by a user.

14. The signal processing method according to claim 11, wherein said plurality of locations for the illumination of the light and a plurality of locations for detection of the light are alternately located in the form of a lattice.