Mesoporous compositions for use in drug delivery

• US 7,172,770 B2
• Filed: 02/19/2002
• Issued: 02/06/2007
• Est. Priority Date: 02/19/2001
• Status: Expired due to Fees

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Balkus, Kenneth J. Jr., Ma, Ying
• Primary Examiner(s): Webman; Edward J.
• Application Number:
  US10/079,443
• Publication Number:
  US 20020164380A1
• Time in Patent Office: 1,813 Days
• Field of Search: 264/41, 424/484, 424/691, 424/400, 424/489
• US Class Current: 424/691
• CPC Class Codes: A61K 9/143 with inorganic compounds
• CPC Class Codes: A61K 9/145 with organic compounds
• CPC Class Codes: A61P 39/06 Free radical scavengers or antioxidants

Abstract

The present invention encompasses novel mesoporous compositions comprising vitamin E and alumina, and methods for their synthesis. The mesoporous compositions of the present invention have applications as drug-delivery vehicles.

Claims

1. A method for preparing a mesoporous composition, comprising the steps of:

(A) dissolving a first compound possessing amphipathic properties together with an alumina source in a first solvent to form a mixture, wherein said first compound comprises polyethyleneoxide moieties and is capable of forming a micellar structure, and wherein the first compound is an alpha-tocopherol polyethylene glycol ester;

(B) stirring the mixture of step (A);

(C) adding a second solvent to the stirred mixture of step (B) accompanied by further stirring;

(D) aging the further stirred mixture of step (C) to form a product, wherein the aging is carried out for 2–

7 days at 70–

95°

C.;

(E) evaporating the product of step (D); and

,

(F) washing, filtering and drying the evaporated product of step (E).

2. The method of claim 1, wherein the alpha-tocopherol polyethylene glycol ester is d-alpha-tocopheryl polyethylene glycol succinate (vitamin E TPGS).

3. The method of claim 1, wherein the first solvent of step (A) is selected from the group consisting of sec-butanol, ethanol and water.

4. The method of claim 1, wherein the alumina source is Al tri-sec-butoxide.

5. The method of claim 1, wherein step (B) is carried out at 25–

30°

C. for 3–

4 hours.

6. The method of claim 1, wherein the aging in step (D) is more preferably carried out at 90°

C. for 2 days.

7. The method of claim 1, wherein the product of step (D) is evaporated at 90°

C. for 10 hours.

8. The method of claim 2 wherein, the amount of vitamin E TPGS ranges from 0.3 to 0.9 g.

9. The method of claim 3 wherein, the amount of sec-butanol is 25 ml.

10. The method of claim 1, wherein said second solvent comprises water and sec-butanol.

11. The method of claim 10, wherein the amount of water is 1.08 g and the amount of sec-butanol is 10 ml.

12. The method of claim 1, wherein the further stirred mixture of step (C) comprises alumina, vitamin E TPGS, water and sec-butanol.

13. The method of claim 12, wherein the molar ratio of alumina, vitamin E TPGS, water and sec-butanol is 100:

1–

3;

300;

270.