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Methods and gel compositions for encapsulating living cells and organic molecules

  • US 7,172,866 B2
  • Filed: 04/02/2002
  • Issued: 02/06/2007
  • Est. Priority Date: 04/03/2001
  • Status: Expired due to Term
First Claim
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1. A bioassay comprising the steps of:

  • (a) providing a microarray which comprises a substrate having a plurality of discrete spots of a stabilized hydrogel composition bound thereto which composition is the reaction product of a prepolymer of polyethylene glycol, polypropylene glycol, or a copolymer thereof having isocyanate end groups, and a thio-functional crossliniking agent, which results in thio-urethane groups wherein said stabilized hydrogel composition further includes biologics encapsulated therewithin which remain bioactive;

    (b) contacting the microarray with an analyte solution, and(c) detecting the interactions of the microarray with the analyte solution.

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