Electrical stimulation strategies to reduce the incidence of seizures
First Claim
1. A method for treating a disorder in a brain of a patient, the method comprising the steps of:
- providing a non-responsive stimulation signal to the brain;
detecting a neurological event; and
providing a responsive stimulation signal in response to the neurological event;
wherein the non-responsive stimulation signal is a non-pulsatile waveform.
2 Assignments
0 Petitions
Accused Products
Abstract
An implantable multimodal neurostimulator having improved efficacy in treating epilepsy and other neurological disorders and processes of using that neurostimulator are described herein. The neurostimulator itself generally has two modes of electrical stimulation. The first involves delivering a non-responsive electrical stimulation signal that is applied to the central nervous system to reduce the likelihood of a seizure or other undesirable neurological even from occurring. Various waveform morphologies are described for non-responsive stimulation signals. A second mode involves delivering a responsive electrical stimulation signal when epileptiform waveforms are impending or extant. The responsive electrical stimulation signal is intended to terminate epileptiform activity, e.g., to desynchronize abnormally synchronous brain electrical activity.
-
Citations
24 Claims
-
1. A method for treating a disorder in a brain of a patient, the method comprising the steps of:
-
providing a non-responsive stimulation signal to the brain;
detecting a neurological event; and
providing a responsive stimulation signal in response to the neurological event;
wherein the non-responsive stimulation signal is a non-pulsatile waveform. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
-
-
16. A method for treating a disorder in a brain of a patient, the method comprising the steps of:
-
providing a non-responsive stimulation signal to the brain;
detecting a neurological event; and
providing a responsive stimulation signal in response to the neurological event;
wherein the non-responsive stimulation signal is at least one substantially sinusoidal pulse.
-
-
17. A method for treating a disorder in a brain of a patient, the method comprising the steps of:
-
providing a non-responsive stimulation signal to the brain;
detecting a neurological event; and
providing a responsive stimulation signal in response to the neurological event;
wherein the non-responsive stimulation signal is at least one pulse having a waveform and an amplitude, and wherein the waveform has a derivative approaching zero as the amplitude approaches zero. - View Dependent Claims (18)
-
-
19. A method for treating a disorder in a brain of a patient, the method comprising the steps of:
-
providing a non-responsive stimulation signal to the brain;
detecting a neurological event; and
providing a responsive stimulation signal in response to the neurological event;
wherein the non-responsive stimulation signal has a direct current component.
-
-
20. A method for treating a disorder in a brain of a patient, the method comprising the steps of:
-
providing a non-responsive stimulation signal to the brain;
receiving an input signal from the patient'"'"'s brain while providing the non-responsive stimulation signal;
filtering the input signal to remove an artifact of the non-responsive stimulation signal; and
detecting a neurological event in the input signal. - View Dependent Claims (21, 22, 23)
-
-
24. An implantable neurostimulator for treating a disorder in a brain of a patient, comprising:
-
a brain electrical activity sensor for sensing electrical activity in the brain;
a brain electrical activity analyzer for detecting epileptiform activity in the electrical activity;
a non-responsive electrical signal source adapted to deliver a non-responsive stimulation signal to a location in the patient'"'"'s brain;
a responsive electrical signal source adapted to deliver a responsive stimulation signal to a location in the patient'"'"'s brain in response to the epileptiform activity;
wherein the non-responsive stimulation signal is a substantially continuous non-pulsatile waveform, a waveform having at least one substantially sinusoidal pulse, a waveform having at least one pulse with a waveform and an amplitude and wherein the waveform has a derivative approaching zero as the amplitude approaches zero, or a waveform with a direct current component.
-
Specification