Feedback control of ultrafiltration to prevent hypotension
First Claim
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1. A system for treating blood from a patient comprising:
- an extracorporeal circuit having a blood passage including a blood withdrawal tube, a filter and an infusion tube, said filter having filter blood passage in fluid communication with the withdrawal tube, a blood outlet in fluid communication with the infusion tube, a filter membrane in fluid communication with the blood passage, a filter output section on a side of the membrane opposite to the blood passage, and a filtrate output line in fluid communication with the filter output section;
a biosensor coupled to said extracorporeal circuit and generating a feedback signal indicative of cardiac output of the patient;
a filtrate pump coupled to the filtrate output line and adapted to draw filtrate fluid from the filter at a controlled filtration rate, anda filtrate pump controller regulating the controlled filtration rate based on the feedback signal, wherein the pump controller includes a processor and a memory storing a control algorithm to determine whether a feedback signal threshold is beyond the feedback signal and storing a baseline feedback signal generated by the biosensor during an initial phase of blood filtration treatment, said controller programmed to execute the control algorithm to reduce the controlled filtration if the feedback signal exceeds the feedback signal threshold, wherein the signal threshold is automatically determined by the controller and is a function of the baseline feedback signal.
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Abstract
A method and system for the extracorporeal treatment of blood to remove fluid from the fluid overloaded patient is disclosed that non-invasively measures an oxygen level in the venous blood. The oxygen blood level is used to detect when hypotension is about to occur in a patient. The oxygen level measurements are used as feedback signals. These feedback signals are applied to automatically control the rate of fluid extraction to achieve the desired clinical outcome and avoid precipitating a hypotensive crisis in the patient.
103 Citations
7 Claims
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1. A system for treating blood from a patient comprising:
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an extracorporeal circuit having a blood passage including a blood withdrawal tube, a filter and an infusion tube, said filter having filter blood passage in fluid communication with the withdrawal tube, a blood outlet in fluid communication with the infusion tube, a filter membrane in fluid communication with the blood passage, a filter output section on a side of the membrane opposite to the blood passage, and a filtrate output line in fluid communication with the filter output section; a biosensor coupled to said extracorporeal circuit and generating a feedback signal indicative of cardiac output of the patient; a filtrate pump coupled to the filtrate output line and adapted to draw filtrate fluid from the filter at a controlled filtration rate, and a filtrate pump controller regulating the controlled filtration rate based on the feedback signal, wherein the pump controller includes a processor and a memory storing a control algorithm to determine whether a feedback signal threshold is beyond the feedback signal and storing a baseline feedback signal generated by the biosensor during an initial phase of blood filtration treatment, said controller programmed to execute the control algorithm to reduce the controlled filtration if the feedback signal exceeds the feedback signal threshold, wherein the signal threshold is automatically determined by the controller and is a function of the baseline feedback signal. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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Specification