Angiotensin-(1-7) eluting polymer-coated medical device to reduce restenosis and improve endothelial cell function
First Claim
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1. A medical device comprising:
- a stent having a generally cylindrical shape comprising an outer surface, an inner surface, a first open end and a second open end;
a controlled-release coating comprising an amphiphilic copolymer comprising a PEG methacrylate-cyclohexyl methacrylate copolymer and at least one angiotensin-(1-7) (Ang-(1-7)) receptor agonist;
wherein at least one of said inner or outer surfaces deliver an effective amount of said at least one Ang-(1-7) receptor agonist to a tissue of a mammal.
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Abstract
Medical devices with polymer coatings designed to control the release of angiotensin-(1-7) receptor agonists from medical devices are disclosed. The present application also discloses providing vascular stents with angiotensin-(1-7) receptor agonist-containing controlled-release coatings. Methods for treating or inhibiting post-stent implantation restenosis as well as improving vascular endothelial function in patients are also provided.
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Citations
27 Claims
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1. A medical device comprising:
- a stent having a generally cylindrical shape comprising an outer surface, an inner surface, a first open end and a second open end;
a controlled-release coating comprising an amphiphilic copolymer comprising a PEG methacrylate-cyclohexyl methacrylate copolymer and at least one angiotensin-(1-7) (Ang-(1-7)) receptor agonist;
wherein at least one of said inner or outer surfaces deliver an effective amount of said at least one Ang-(1-7) receptor agonist to a tissue of a mammal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 26)
- a stent having a generally cylindrical shape comprising an outer surface, an inner surface, a first open end and a second open end;
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9. A vascular stent for inhibiting restenosis in a mammal comprising:
- stent having a generally cylindrical shape comprising an outer surface, an inner surface, a first open end and a second open end;
a controlled-release coating comprising a PEG methacrylate-cyclohexyl methacrylate copolymer and an anti-restenotic amount of an Ang-(1-7) receptor agonist peptide having the amino acid sequence of SEQ ID NO. 1; and
a methacrylate copolymer topcoat;
wherein said vascular stent delivers an effective amount of said Ang-(1-7) receptor agonist to a tissue of a mammal. - View Dependent Claims (10, 27)
- stent having a generally cylindrical shape comprising an outer surface, an inner surface, a first open end and a second open end;
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11. A method for inhibiting restenosis in a mammal comprising:
- a vascular stent having a controlled-release coating thereon wherein said coating comprises an amphiphilic copolymer comprising a PEG methacrylate-cyclohexyl methacrylate copolymer and an effective amount of at least one Ang-(1-7) receptor agonist at a treatment site; and
inhibiting restenosis in said mammal. - View Dependent Claims (12, 13, 14, 15, 16, 17)
- a vascular stent having a controlled-release coating thereon wherein said coating comprises an amphiphilic copolymer comprising a PEG methacrylate-cyclohexyl methacrylate copolymer and an effective amount of at least one Ang-(1-7) receptor agonist at a treatment site; and
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18. A method for improving endothelial cell function in a mammal comprising:
- implanting a vascular stent having a controlled-release coating thereon wherein said coating comprises an amphiphilic copolymer comprising a PEG methacrylate-cyclohexyl methacrylate copolymer and an effective amount of at least one Ang-(1-7) receptor agonist at a treatment site; and
improving vascular endothelial cell function in said mammal. - View Dependent Claims (19, 20, 21, 22, 23, 24)
- implanting a vascular stent having a controlled-release coating thereon wherein said coating comprises an amphiphilic copolymer comprising a PEG methacrylate-cyclohexyl methacrylate copolymer and an effective amount of at least one Ang-(1-7) receptor agonist at a treatment site; and
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25. A method for treating impaired vascular endothelial cell function in a mammal comprising:
- implanting a stent having a controlled release coating and an effective amount of Ang-(1-7) disposed on at lease one surface of said medical device at a treatment site in a vessel lumen, wherein said controlled release coating comprises a PEG methacrylate-cyclohexyl methacrylate copolymer;
releasing said Ang-(1-7) from said surface of said stent such that vascular endothelial cell function is improved at said treatment site.
- implanting a stent having a controlled release coating and an effective amount of Ang-(1-7) disposed on at lease one surface of said medical device at a treatment site in a vessel lumen, wherein said controlled release coating comprises a PEG methacrylate-cyclohexyl methacrylate copolymer;
Specification