Using photo-plethysmography to monitor autonomic tone and performing pacing optimization based on monitored autonomic tone
First Claim
1. A method for monitoring autonomic tone of a patient, comprising:
- (a) producing a photo-plethysmography signal that is representative of arterial pulse pressure of the patient; and
(b) monitoring the autonomic tone of the patient based on the photo-plethysmography signal by identifying changes in at least one of sympathetic tone and parasympathetic tone of the patient based on changes in pulse amplitude associated with the photo-plethysmography signal.
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Abstract
The autonomic tone of a patient is measured based on a photo-plethysmography signal that is representative of arterial pulse pressure of the patient. Such measures of autonomic tone can be used to monitor the hemodynamic status of a patient, and even to perform pacing interval optimization. Further embodiments relate to pacing interval optimization performed based on a signal indicative of cardiac contractions of a patient'"'"'s heart, as the patient'"'"'s heart is paced using different sets of pacing interval parameters. Such a signal can be a photo-plethysmography signal or an alternative type of signal. Measures of pulse amplitude are obtained from the signal, and pacing interval optimization is performed based on the measures of pulse amplitude.
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Citations
39 Claims
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1. A method for monitoring autonomic tone of a patient, comprising:
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(a) producing a photo-plethysmography signal that is representative of arterial pulse pressure of the patient; and (b) monitoring the autonomic tone of the patient based on the photo-plethysmography signal by identifying changes in at least one of sympathetic tone and parasympathetic tone of the patient based on changes in pulse amplitude associated with the photo-plethysmography signal.
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2. A method for monitoring autonomic tone of a patient, comprising:
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(a) producing a photo-plethysmography signal that is representative of arterial pulse pressure of the patient; (b) monitoring the autonomic tone of the patient based on the photo-plethysmography signal; (b.1) obtaining measures of pulse amplitude from the photo-plethysmography signal; and (b.2) identifying changes in sympathetic tone of the patient based changes in the measures of pulse amplitude. - View Dependent Claims (3, 4, 5, 6)
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7. A method for monitoring autonomic tone of a patient, comprising:
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(a) producing a photo-plethysmography signal that is representative of arterial pulse pressure of the patient; (b) monitoring the autonomic tone of the patient based on the photo-plethysmography signal; (b.1) obtaining measures of pulse amplitude from the photo-plethysmography signal; and (b.2) identifying changes in parasympathetic tone of the patient based changes in the measures of pulse amplitude. - View Dependent Claims (8, 9, 10, 11)
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12. A method for monitoring autonomic tone of a patient, comprising:
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(a) producing a photo-plethysmography signal that is representative of arterial pulse pressure of the patient using a light source and a detector, that are extravascularly implanted in the patient, to produce the photo-plethysmography signal; and (b) monitoring the autonomic tone of the patient based on the photo-plethysmography signal.
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13. A system for monitoring autonomic tone of a patient, comprising:
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a light source and a detector to produce a photo-plethysmography signal that is representative of arterial pulse pressure of a patient; and a means for monitoring the autonomic tone of the patient based on the photo-plethysmography signal, wherein the means for monitoring autonomic tone is adapted to identify changes in at least one of sympathetic tone and parasympathetic tone of the patient based on changes in pulse amplitude associated with the photo-plethysmography signal.
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14. A system for monitoring autonomic tone of a patient, comprising:
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a light source and a detector to produce a photo-plethysmography signal that is representative of arterial pulse pressure of a patient; and a means for monitoring the autonomic tone of the patient based on the photo-plethysmography signal, wherein the light source and the detector are incorporated into an implantable device.
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15. A system for monitoring autonomic tone of a patient, comprising:
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a light source and a detector to produce a photo-plethysmography signal that is representative of arterial pulse pressure of a patient; and a means for monitoring the autonomic tone of the patient based on the photo-plethysmography signal, wherein the means for monitoring autonomic tone is adapted to recognize an increase in pulse amplitude variability as a decrease in the sympathetic tone of the patient.
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16. A method for performing pacing interval optimization, comprising:
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(a) producing a photo-plethysmography signal that is representative of arterial pulse pressure of the patient, as the patient'"'"'s heart is paced using different sets of pacing interval parameters; (b) monitoring the autonomic tone of the patient, based on the photo-plethysmography signal; and (c) performing pacing interval optimization based on the monitored autonomic tone. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A system for performing pacing interval optimization, comprising:
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a pacing circuit to pace a patient'"'"'s heart using different sets of pacing interval parameters; a light source and a detector to produce a photo-plethysmography signal that is representative of arterial pulse pressure of a patient, as the patient'"'"'s heart is paced using the different sets of pacing interval parameters; and a processor adapted to monitor the autonomic tone of the patient based on the photo-plethysmography signal, and to perform pacing interval optimization based on the monitored autonomic tone. - View Dependent Claims (32, 33)
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34. A method for performing pacing interval optimization, comprising:
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(a) producing a photo-plethysmography signal that is representative of arterial pulse pressure of the patient, as the patient'"'"'s heart is paced using different sets of pacing interval parameters; (b) performing pacing interval optimization by using measures of the photo-plethysmography signal as indicators of cardiac performance. - View Dependent Claims (35, 36, 37, 38, 39)
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Specification