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Parallel fluid processing systems and methods

  • US 7,178,386 B1
  • Filed: 04/09/2004
  • Issued: 02/20/2007
  • Est. Priority Date: 04/10/2003
  • Status: Active Grant
First Claim
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1. A multi-column liquid chromatography data correction methods comprising the steps of:

  • providing a plurality of liquid chromatography columns in fluid communication with a common mobile phase source, each column of the plurality of columns containing a stationary phase material, wherein the mobile phase source supplies a mobile phase to the plurality of columns at a selected mobile phase source output flow rate;

    providing at least one detector in sensory communication with the plurality of columns;

    supplying a calibrant having at least a first component to each column of the plurality of columns;

    eluting the at least a first component of the calibrant in each column of the plurality columns according to a first mobile phase source output flow rate and a first mobile phase composition profile;

    measuring, for each column of the plurality of columns, a first physical parameter using the at least one detector;

    deriving, for each column of the plurality of columns, at least one correction factor based on the first physical parameter;

    supplying, to each column of the plurality of columns, at least one sample containing a plurality of sample components;

    eluting at least two components of the plurality of sample components of the at least one sample in each column of the plurality of columns to obtain raw chromatographic data; and

    applying, for each column of the plurality of columns, the at least one correction factor to the raw chromatographic data to yield corrected chromatographic output data.

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