Thermosensitive biodegradable copolymer

• US 7,179,867 B2
• Filed: 11/26/2003
• Issued: 02/20/2007
• Est. Priority Date: 11/26/2003
• Status: Active Grant

• Current Assignee: Industrial Technology Research Institute
• Original Assignee: Industrial Technology Research Institute
• Inventors: Lin, Xi-Zhang, Chang, Ken-Yuan, Kan, Pei, Jan, Shu-Hua, Hsieh, Ming-Fa, Jan, Yu-Yan, Yeh, Ming-Hsi
• Primary Examiner(s): PENG, KUO LIANG
• Application Number:
  US10/721,877
• Publication Number:
  US 20050113531A1
• Time in Patent Office: 1,182 Days
• Field of Search: None
• US Class Current: 525/410
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61L 24/0042 Materials resorbable by the body
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: C08G 2261/126 block
• CPC Class Codes: C08G 63/664 derived from hydroxy carboxylic acids
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

A thermo-sensitve copolymer of following formula;

is disclosed; wherein R₁ is hydrogen, or —C(═O)—R₂; R₂ is C_7-30 alkyl substituted or unsubstituted with functional groups; R₃ is hydrogen, or C_1-6 alkyl; and x, y or z individually is an integer greater than 0. The thermo-sensitive copolymers disclosed here are easy to be implanted into a human body through injection. The biodegradability is greatly improved and the cytotoxicity of the copolymers is low.

Claims

1. A biodegradable block copolymer of the following formula (I):

2. The polymer as claimed in claim 1, wherein said R₃ is methyl.

3. The polymer as claimed in claim 1, wherein said polymer is applied for drug releasing or embolic agents.

4. The polymer as claimed in claim 1 wherein x:

y;

z is 3–

18;

11–

66;

4–

114.

5. The polymer as claimed in claim 1, wherein said polymer is functioned as an embolic agent.