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Combinatorial selection of oligonucleotide aptamers

  • US 7,179,894 B2
  • Filed: 04/11/2002
  • Issued: 02/20/2007
  • Est. Priority Date: 10/26/1998
  • Status: Expired due to Term
First Claim
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1. A NF-IL6 protein binding aptamer comprising a mix of unmodified and thiophosphate-modified nucleotides that form a partially thiophosphate-modified oligonucleotide identified by SEQ ID NO:

  • 7, wherein at least one but no more than four of any one single nucleotide base is thiophosphate-modified, wherein the aptamer binds NF-IL6.

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