Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
First Claim
1. A nucleic acid molecule comprising a nucleotide sequence encoding a variable light (VL) chain of an antibody that immunospecifically binds to a respiratory syncytial virus (RSV) F antigen, wherein the VL chain comprises the amino acid sequence of SEQ ID NO:
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Abstract
The present invention encompasses novel antibodies and fragments thereof which immunospecifically bind to one or more RSV antigens and compositions comprising said antibodies and antibody fragments. The present invention encompasses methods preventing respiratory syncytial virus (RSV) infection in a human, comprising administering to said human a prophylactically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention also encompasses methods for treating or ameliorating symptoms associated with a RSV infection in a human, comprising administering to said human a therapeutically effective amount of one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens, wherein a certain serum titer of said antibodies or antibody fragments is achieved in said human subject. The present invention further encompasses compositions comprising antibodies or fragments thereof that immunospecifically bind to a RSV antigen, and methods using said compositions for detection or diagnosis of a RSV infection.
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Citations
80 Claims
- 1. A nucleic acid molecule comprising a nucleotide sequence encoding a variable light (VL) chain of an antibody that immunospecifically binds to a respiratory syncytial virus (RSV) F antigen, wherein the VL chain comprises the amino acid sequence of SEQ ID NO:
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2. A nucleic acid molecule comprising a nucleotide sequence encoding a variable heavy (VH) chain of an antibody that immunospecifically binds to a RSV F antigen, wherein the VH chain comprises the amino acid sequence of SEQ ID NO:
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- 4. A nucleic acid molecule comprising a nucleotide sequence encoding a VL domain of an antibody that immunospecifically binds to a RSV F antigen, wherein the VL domain comprises the amino acid sequence of SEQ ID NO:
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5. A nucleic acid molecule comprising a nucleotide sequence encoding a VH domain of an antibody that immunospecifically binds to a RSV F antigen, wherein the VH domain comprises the amino acid sequence of SEQ ID NO:
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- 7. A nucleic acid molecule comprising a nucleotide sequence encoding a VH domain of an antibody that immunospecifically binds to a RSV F antigen, wherein the VH domain comprises a VH complementarity determining region (CDR) 1 comprising the amino acid sequence of SEQ ID NO:
- 8. A nucleic acid molecule comprising a nucleotide sequence encoding a VH domain of an antibody that immunospecifically binds to a RSV F antigen, wherein the VH domain comprises a VH CDR2 comprising the amino acid sequence of SEQ ID NO:
- 9. A nucleic acid molecule comprising a nucleotide sequence encoding a VH domain of an antibody that immunospecifically binds to a RSV F antigen, wherein the VH domain comprises a VH CDR3 comprising the amino acid sequence of SEQ ID NO:
- 10. A nucleic acid molecule comprising a nucleotide sequence encoding a VL domain of an antibody that immunospecifically binds to a RSV F antigen, wherein the VL domain comprises a VL CDR1 comprising the amino acid sequence of SEQ ID NO:
Specification