Biological adhesive loading station and method

• US 7,182,107 B2
• Filed: 12/15/2003
• Issued: 02/27/2007
• Est. Priority Date: 01/14/2002
• Status: Active Grant

• Current Assignee: Asahi Kasei Medical Co., Ltd. (Asahi Kasei Corporation)
• Original Assignee: The Thermogenesis Corporation (Cesca Therapeutics Incorporated)
• Inventors: Sommer, Eric, Coelho, Philip Henry, Kingsley, Phil
• Primary Examiner(s): Huynh; Khoa D.
• Application Number:
  US10/737,066
• Publication Number:
  US 20040140012A1
• Time in Patent Office: 1,170 Days
• Field of Search: 141/9, 141/99, 141/100, 141/104, 141/114, 141/236
• US Class Current: 141/9
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 2017/00495 for two-component glue

Abstract

A loading station having a dispensing manifold for loading syringe pairs with thrombin and adhesive and clotting proteins for use as a biological adhesive. The resulting loaded syringe pairs are compatible with a variety of biological adhesive dispensers and may be used in a surgical setting.

Claims

1. A method for loading dispensing means with thrombin and clotting proteins, the steps including:

attaching a plurality of said dispensing means to separate dispensing lines containing thrombin and clotting proteins;

manipulating said plurality of dispensing means to purge air in each of said dispensing lines;

sequentially filling said plurality of dispensing means through each of said dispensing lines;

clustering said plurality of dispensing means in pairs, with one of each said pair of dispensing means receiving thrombin and the other receiving clotting proteins;

equipping each said dispensing means with a removable fitting for connection to one said dispensing line;

securing each said pair of dispensing means in a frame, said frame including a retaining member; and

ensconcing each of said pairs of dispensing means in a membrane.

2. The method of claim 1 further including the step of:

maintaining contents of said dispensing means at a desired temperature after filling.

3. The method of claim 1 further including the step of:

introducing each said pair of dispensing means into a spraying means, said spraying means having means for simultaneous delivery of the thrombin and clotting proteins.

4. The method of claim 3 further including the step of:

maintaining contents of said dispensing means in said spraying means at a desired temperature after filling.

5. A method for loading dispensing means with thrombin and clotting proteins, the steps including;

attaching a plurality of said dispensing means to separate dispensing lines containing thrombin and clotting proteins;

manipulating said plurality of dispensing means to purge air in each of said dispensing lines;

sequentially filling said plurality of dispensing means through each of said dispensing lines;

clustering said plurality of dispensing means in pairs, with one of each said pair of dispensing means receiving thrombin and the other receiving clotting proteins;

equipping each said dispensing means with a removable fitting for connection to one said dispensing line;

securing each said pair of dispensing means in a frame, said frame including a retaining member;

forming a membrane, said membrane having a gathered portion of accordion folds; and

ensconcing each said pair of dispensing means in a separate membrane such that said membrane opens at an end opposite said dispensing lines, whereby removal or adjustment of said dispensing means may occur.

6. The method of claim 5 further including the step of:

maintaining contents of said dispensing means at a desired temperature after filling.

7. The method of claim 5 further including the step of:

introducing each said pair of dispensing means into a spraying means, said spraying means having means for simultaneous delivery of the thrombin and clotting proteins.

8. The method of claim 7 further including the step of:

maintaining contents of said dispensing means in said spraying means at a desired temperature after filling.