Solid solution perforator for drug delivery and other applications
First Claim
1. An array comprising a plurality of dissolvable, substantially solid, drug solution delivery perforators, wherein each perforator comprises a first end with at least one point or blade adapted for penetrating skin and for providing a skin aperture on a patient'"'"'s body, and further wherein at least one of the perforators is formed from a matrix material that comprises sodium carboxymethyl cellulose, is dissolvable and includes a first selected drug distributed within the matrix, the perforators dissolving over a time interval of between a few tens of seconds and a few hours after the perforator has been inserted into a patient'"'"'s body.
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Accused Products
Abstract
A solid drug solution perforator (SSP) system and an associated drug reservoir are provided for delivering therapeutic, prophylactic and/or cosmetic compounds, for nutrient delivery and for drug targeting. For drug delivery, the SSP system includes an active drug ingredient and a matrix of perforator material that biodegrades or dissolves quickly upon contact with a patient'"'"'s body. The SSP system provides a skin barrier perforator and a controller for prompt initiation and cut-off of drug delivery. In a preferred method of transdermal drug delivery, an SSP system containing a selected drug penetrates into an epidermis or dermis, and the drug is promptly released from the (dissolving) SSP system perforator. An additional drug is optionally delivered from a patch reservoir through skin pores created by insertion of the perforator. Formulation and fabrication procedures for the SSP and associated reservoir are also provided. An SSP system can be fabricated with variety of shapes and dimensions.
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Citations
23 Claims
- 1. An array comprising a plurality of dissolvable, substantially solid, drug solution delivery perforators, wherein each perforator comprises a first end with at least one point or blade adapted for penetrating skin and for providing a skin aperture on a patient'"'"'s body, and further wherein at least one of the perforators is formed from a matrix material that comprises sodium carboxymethyl cellulose, is dissolvable and includes a first selected drug distributed within the matrix, the perforators dissolving over a time interval of between a few tens of seconds and a few hours after the perforator has been inserted into a patient'"'"'s body.
Specification