Shrinkage of dilatations in the body

• US 7,184,827 B1
• Filed: 01/24/2000
• Issued: 02/27/2007
• Est. Priority Date: 01/24/2000
• Status: Expired due to Fees

• Current Assignee: Stuart D. Edwards
• Original Assignee: Stuart D. Edwards
• Inventors: Edwards, Stuart D.
• Primary Examiner(s): Lucchesi; Nicholas D.
• Assistant Examiner(s): SNYDER, MELISSA A
• Application Number:
  US09/490,622
• Time in Patent Office: 2,591 Days
• Field of Search: 604/21, 604/20, 604/19, 604/101.05, 604/103.01, 604/509, 604/96.01, 604/913, 604/95.05, 604/113, 604/508, 606 27- 29, 606/31, 606/32, 606 41- 45, 606/200, 606/192, 606/46, 607/122, 607/101, 623/17.16, 623/17.12, 623/23.72, 623/902, 623/18.11, 128/898
• US Class Current: 604/21
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 2025/1095 with perfusion means for enabling blood circulation while the balloon is in an inflated state or in a deflated state, e.g. permanent by-pass within catheter shaft
• CPC Class Codes: A61M 2205/36 related to heating or cooling
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters

Abstract

A method and system for shrinking dilatations of a body, removing excess, weak or diseased tissue, and strengthening remaining tissues of the lumen walls. A catheter is disposed near the dilatation and fixed in position by inflatable occlusion balloons. Body fluids present in the occluded dilatation are evacuated and treatment fluid is exuded under pressure into the dilatation. Pressure is maintained by the treatment fluid while energy is applied by the catheter to heat the treatment fluid, causing the lumen walls to absorb the treatment fluid. Additional energy is then applied so as to preferentially heat the lumen wall tissues which have absorbed the treatment fluid, while at the same time treatment fluid is circulated to cool the inner surface of the lumen walls. The dilatation is occluded, a saline solution is introduced and absorbed into the lumen-wall tissue in the occluded region of the dilatation and then heated by application of radio frequency (“RF”) or other energy in order to soften only the lumen-wall tissue of the dilatation, the dilatation is shrunk by application of a chilled saline solution and a vacuum, and additional RF or other energy is emitted to ablate, further shrink, and harden only the lumen-wall tissue of the dilatation, without destroying the inner surface of the lumen or other tissues of the body beyond the lumen walls, thereby promoting growth of epithelial cells.

Claims

1. A method for treating a dilatation of a body, including the steps of:

inserting a catheter into a localized region of said body;

exuding from said catheter a substance capable of perfusing into at least some tissue in said localized region and allowing said substance to perfuse into a tissue of said localized region;

emitting from said catheter energy of a frequency and in an amount effective to heat the substance to a temperature at which it is readily absorbed into a wall of said dilatation;

softening tissue of a wall of said dilatation by application of additional energy at a frequency and power level effective to preferentially heat said tissue of said walls while minimizing thermal injury to an inner surface of said dilatation; and

permanently contracting said dilatation by applying a vacuum by means of at least one suction port so that the dilatation shrinks to a desired diameter.

2. A method as in claim 1, wherein said localized region Includes a lumen or sphincter.

3. A method as in claim 1, wherein said localized region includes cancerous, engorged, inflamed or infected tissue.

4. A method as in claim 1, wherein said localized region includes an aneurysm, a blocked lumen, a stenosed lumen or a constricted lumen.

5. A method as in claim 1, wherein said localized region includes a cyst, tumor or wart.

6. A method as in claim 1, wherein said localized region is associated with a body system, said body system including a blood vessel, lung tube, lung pocket, gastrointestinal system, urogenital system, nerve or nerve sheath.

7. A method as In claim 1, wherein said localized region is associated with a particular organ Including a kidney, prostate, retinal lesion or skin lesion.

8. A method as in claim 1, wherein said exuded substance includes a saline solution.

9. A method as in claim 1, wherein said exuded substance includes a non-toxic foam.

10. A method as in claim 1, wherein said exuded substance includes a collagen.

11. A method as in claim 1, wherein said exuded substance includes a bioactive substance, said substance including a drug or enzyme.

12. A method as in claim 1, wherein said exuded substance includes a chemoactive substance including an acid, lipid-breaker or soap.

13. A method as in claim 1, wherein said exuded substance includes an instrumentative substance including a florescent or x-ray marker.

14. A method as in claim 1, wherein said energy is emitted by electrical contact.

15. A method as in claim 1, wherein said emitted energy includes RF (monopolar or bipolar), microwave or laser.

16. A method as in claim 1, wherein said emitted energy includes ultrasound.

17. A method as in claim 1, wherein said emitted energy includes physical heating or cooling.

18. A method as in claim 2, wherein treatment includes shrinkage of said lumen or said sphincter to a selected dimension.

19. A method as In claim 2, wherein treatment includes shrinkage of said lumen or said sphincter to a substantially normal dimension.

20. A method as in claim 1, wherein treatment includes shrinkage of said engorged or inflamed tissue by removal of lipids or water.

21. A method as in claim 1, wherein treatment includes shrinkage of said engorged or inflamed tissue by removal of an ablated tissue or a dead cell matter.

22. A method as in claim 1, wherein treatment includes shrinkage of said engorged or inflamed tissue by removal of infection products.

23. A method as in claim 1, wherein treatment includes destruction of a damaged or a diseased tissue.

24. A method as in claim 1, wherein treatment includes promotion of epithelial growth.

25. A method as in claim 1, wherein treatment avoids local nerve centers.

26. A method as in claim 1, including an additional step of isolating said localized region using a structure inserted as part of said catheter.

27. A method as in claim 26, wherein said inserted structure includes an occluding balloon.

28. A method as in claim 26, wherein said inserted structure includes a space-filling balloon with a lumen through it.

29. A method as in claim 1, wherein said catheter includes instrumentation used for feedback.

30. A method as in claim 29, wherein said feedback includes surgical visualization provided by a camera, RF energy, x-rays, florescence or ultrasound.

31. A method as in claim 29, wherein said feedback includes systemic feedback, comprising measurement of pH, pressure or temperature.

32. A method as in claim 29, wherein said feedback includes monitoring for said treatment, including an element for determining a location of a specified tissue element to be treated.

33. A method as in claim 29, wherein said feedback includes monitoring for said treatment, including pacing.

34. A method as In claim 1, wherein said exuding and perfusing includes a physical method of delivery.

35. A method as in claim 34, wherein said exuded and perfused substance includes a saline solution or nontoxic foam.

36. A method as In claim 34, wherein said physical method of delivery includes a porous balloon, a microporous balloon, or a balloon with a porous or microporous membrane.

37. A method as in claim 34, wherein said physical method of delivery includes direct emission from said catheter.

38. A method as in claim 34, wherein said physical method of delivery includes a local structure, comprising an absorbable basket or a stent.