Calibration of a doppler velocimeter for stroke volume determination

• US 7,186,219 B2
• Filed: 10/10/2002
• Issued: 03/06/2007
• Est. Priority Date: 10/11/2001
• Status: Expired due to Term

• Current Assignee: Osypka Medical GmbH
• Original Assignee: Osypka Medical GmbH
• Inventors: Bernstein, Donald P., Osypka, Markus J.
• Primary Examiner(s): Nasser; Robert L.
• Application Number:
  US10/268,120
• Publication Number:
  US 20030163056A1
• Time in Patent Office: 1,608 Days
• Field of Search: 600/505, 600/547, 600478-480, 600/465
• US Class Current: 600/504
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter
• CPC Class Codes: A61B 5/4233 oesophagus
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00

Abstract

Doppler Velocimetry is a widely used method for estimating stroke volume (SV). The accuracy and reliability of its measurement however, is dependant on

• a) the correct assessment of the aortic valve cross-sectional area (CSA), and
• b) the maximal systolic velocity integral (SVI).
  The invention avoids the conventional assessment of aortic valve CSA by using a calibration method: a reference stroke volume SV_REF is determined by a method different from Doppler velocimetry, e.g. by thoracic electrical bioimpedance (TEB), or thoracic electrical bioadmittance, measured via surface thorax electrodes (transthoracic approach) or via electrodes located directly on an esophageal catheter/probe (esophageal approach). In the latter case, if esophageal Doppler velocimetry is used, the same catheter can be used for the placement of the electrodes and for an ultrasound transducer. In the case of esophageal Doppler velocimetry, an additional benefit of the invention is that the Doppler catheter/probe does not need to be aimed precisely at the site of maximum flow amplitude, as long as a stable catheter/probe location is maintained within the esophagus.

Claims

1. A method of monitoring the stroke volume (SV) of a subject'"'"'s heart at different time periods, comprising the steps of:

determining a reference stroke volume (SV_REF) of the subject'"'"'s heart by a first method different from Doppler velocimetry in a first time period;

simultaneously determining a reference systolic velocity integral (SVI_CAL) by Doppler velocimetry;

calculating a constant k_CAL, wherein

k_CAL=SV_REF/SVI_CAL;

determining a systolic velocity integral (SVI) at later time periods by Doppler velocimetry; and

determining the stroke volume (SV) at said later periods by setting SV=k_CAL·

SVL.

2. The method of claim 1, wherein said first method uses one of the group of transthoracic electrical impedance measurements and transthoracic electrical bioadmittance measurements.

3. The method of claim 1, wherein said first method uses one of the group of esophageal electrical bioimpedance measurements and esophageal electrical bioadmittance measurements.

4. The method of claim 1, wherein esophageal Doppler velocimetry is used.

5. The method of claim 4, wherein, prior to determining said reference stroke volume (SV_REF) and said reference systolic velocity integral (SVI_CAL),

a) a catheter comprising a device for performing Doppler velocimetry by obtaining Doppler signals is inserted into the subject'"'"'s esophagus,

b) said catheter is rotated until substantially maximal Doppler signal strength is obtained, and

c) said catheter is fixed such that it can no longer be rotated.

6. The method of claim 4, wherein a catheter comprising a device for performing Doppler velocimetry is inserted into the subject'"'"'s esophagus, and wherein it is attempted to hold the catheter fixed starting at least from said determination of said reference stroke volume (SV_REF) and said reference systolic velocity integral (SVI_CAL), and

wherein after each movement of said catheter, despite said attempt to hold the catheter fixed, said reference stroke volume (SV_REF) and said reference systolic velocity integral (SVI_CAL) are newly determined and said constant k_CAL is newly calculated, and

wherein said newly calculated k_CAL is used for the determination of the stroke volume (SV) until a new movement of said cathete occurs.

7. The method of claim 1, wherein during said Doppler velocimetry, a transducer is applied to the suprasternal acoustic window.

8. A method of monitoring the cardiac output (CO) of a subject'"'"'s heart, comprising:

determining the stroke volume (SV) of the subject'"'"'s heart by using the method according to claim 1;

determining the heart rate (HR) of the subject'"'"'s heart; and

calculating the cardiac output as,

CO=SV·

HR.

9. The method according to claim 8, wherein the heart rate (HR) is determined by using an electrocardiogram.

10. A system for monitoring the stroke volume (SV) of a subject'"'"'s heart at different times, comprising:

a reference device for determining a reference stroke volume (SV_REF) by using a first method different from Doppler velocimetry;

a Doppler velocimeter for determining reference systolic velocity integral (SVI_REF) and systolic velocity integral (SVI) at different times; and

a device for calculating, said calculating device being adapted to obtain the reference stroke volume (SV_REF) from said reference device and the systolic velocity integral from said velocimeter.

11. A system for monitoring the stroke volume (SV) of a subject'"'"'s heart at different times, comprising:

a reference device for determining a reference stroke volume (SV_REF) by using a first method different from Doppler velocimetry;

a Doppler velocimeter for determining reference systolic velocity integral (SVI_REF) and systolic velocity integral (SVI) at different times;

a device for calculating; and

a controller for switching between;

a) a calibration mode in which said reference device and said Doppler velocimeter are activated, and

b) a measurement mode in which only said Doppler velocimeter is activated.

12. An apparatus for monitoring the stroke volume (SV) of a subject'"'"'s heart at different times, comprising:

a thoracic impedance measuring unit, including;

an alternating current (AC) source connected to two ports for attaching electrodes, and

a voltmeter connected to two ports for attaching electrodes;

a Doppler velocimeter unit including a controller for controlling an ultrasound emitter and a signal receiving device for obtaining signals from an ultrasound receiver; and

a processing unit connected to said thoracic impedance measuring unit and said Doppler velocimeter unit, said processing unit being adapted to obtain a reference stroke volume (SV_REF) from said thoracic impedance measuring unit and a systolic velocity integral from said velocimeter.

13. The apparatus of claim 12, further comprising an interface for inputting data into said processing unit.

14. The apparatus of claim 12, further comprising a display.

15. A system for monitoring the stroke volume (SV) of a subject'"'"'s heart, comprising:

the apparatus of claim 12; and

a catheter which is adapted to be inserted into the subject'"'"'s esophagus, wherein an ultrasound transducer is mounted on said catheter, said transducer being electrically connected to said Doppler velocimetry unit of said apparatus.

16. The system of claim 15, wherein four electrodes are mounted in two pairs on said catheter and wherein a first electrode of each pair is electrically connected to said alternating current (AC) source of said apparatus and a second electrode of each pair is electrically connected to said voltmeter of said apparatus, and wherein said second electrodes are located closer to each other than said first electrodes.

17. The apparatus of claim 12, further comprising a device adapted to be inserted into a subject'"'"'s esophagus, said device comprising:

a catheter,

at least two electrodes on the catheter; and

an ultrasound emitter and ultrasound receiver for Doppler velocimetry on the catheter.

18. The apparatus of claim 17, wherein said transducer is placed in the center of the electrodes.

19. The apparatus of claim 18, wherein four electrodes are mounted on the catheter in a pairwise arrangement, one of said pairs being placed nearer to the transducer than the other pair.