Methods and systems for correcting image misalignment
First Claim
Patent Images
1. A method of compensating for image misalignment, the method comprising the steps of:
- obtaining a set of sequential images of a tissue sample; and
correcting for a misalignment between each of a pluarlity of pairs of the sequential images, the misalignment due at least in part to movement of the tissue sample, wherein the correcting step comprises determining a correction for a misalignment between a pair of the sequential images less than about 2 seconds after obtaining the latter of the pair of images.
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Abstract
The invention provides methods of determining a correction for a misalignment between at least two images in a sequence of images due at least in part to sample movement. The methods are applied, for example, in the processing and analysis of a sequence of images of biological tissue in a diagnostic procedure. The invention also provides methods of validating the correction for a misalignment between at least two images in a sequence of images of a sample. The methods may be applied in deciding whether a correction for misalignment accurately accounts for sample motion.
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51 Claims
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1. A method of compensating for image misalignment, the method comprising the steps of:
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obtaining a set of sequential images of a tissue sample; and correcting for a misalignment between each of a pluarlity of pairs of the sequential images, the misalignment due at least in part to movement of the tissue sample, wherein the correcting step comprises determining a correction for a misalignment between a pair of the sequential images less than about 2 seconds after obtaining the latter of the pair of images. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. A system for compensating for image misalignment, the system comprising:
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an optical signal detection device configured to obtain a set of sequential images of a tissue sample; and a processor configured to determine a correction for a misalignment between each of a plurality of pairs of the sequential images, the misalignment due at least in part to movement of the tissue sample, wherein the correction between a pair of the sequential images is determined less than about 2 seconds after obtaining the latter of the pair of images. - View Dependent Claims (43, 44, 45, 46, 47, 48)
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49. A method of compensating for image misalignment, the method comprising the steps of:
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obtaining a sequence of images of a tissue sample; and correcting for misalignment between at least two of the images, said misalignment being due at least in part to movement of the tissue sample, wherein the correcting step comprises adjusting a position of a mirror of an optical signal detection device used to obtain the sequence of images.
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50. A method of compensating for image misalignment, the method comprising the steps of:
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obtaining a sequence of images of a tissue sample; and correcting for misalignment between at least two of the images, said misalignment being due at least in part to movement of the tissue sample, wherein the correcting step comprises the step of filtering a subset of data from at least one image of the sequence of images using a feathering technique.
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51. A method of compensating for image misalignment, the method comprising the steps of:
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obtaining a sequence of images of a tissue sample; and correcting for misalignment between at least two of the images, said misalignment being due at least in part to movement of the tissue sample, wherein the correcting step comprises the step of filtering a subset of data from at least one image of the sequence of images using a Hamming window.
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Specification