Substituted porphyrins

• US 7,189,707 B2
• Filed: 01/23/2003
• Issued: 03/13/2007
• Est. Priority Date: 01/25/1999
• Status: Expired due to Fees

• Current Assignee: Duke University, National Jewish Health
• Original Assignee: Aeolus Sciences Incorporated, Duke University, National Jewish Medical and Research Center
• Inventors: Kitchen, Douglas B., Day, Brian J., Fridovich, Irwin, Trova, Michael P., Batinic-Haberle, Ines, Crapo, James D., Gauuan, Polivina Jolicia F.
• Primary Examiner(s): PRYOR, ALTON NATHANIEL
• Application Number:
  US10/349,171
• Publication Number:
  US 20040023941A1
• Time in Patent Office: 1,510 Days
• Field of Search: 514/185, 514/365, 514/383, 514/397, 514/406, 514/410
• US Class Current: 514/185
• CPC Class Codes: A61K 31/409 having four such rings, e.g. porphine derivatives, bilirubin, biliverdine hemin, hematin A61K31/555
• CPC Class Codes: A61K 31/555 containing heavy metals, e.g. hemin, hematin, melarsoprol
• CPC Class Codes: A61P 11/00 Drugs for disorders of the respiratory system
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 39/00 General protective or antinoxious agents
• CPC Class Codes: A61P 39/06 Free radical scavengers or antioxidants
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 487/22 in which the condensed system contains four or more hetero rings
• CPC Class Codes: C09B 47/00 Porphines; Azaporphines non-dyeing compounds C07D487/22

Abstract

The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.

Claims

1. A method of protecting cells from oxidant-induced toxicity comprising contacting said cells with an effective amount of a compound of formula

2. The method according to claim 1 wherein said compound is complexed with a metal selected from the group consisting of manganese, iron, copper, cobalt, nickel or zinc.

3. The method according to claim 2 wherein said metal is manganese.

4. The method according to claim 1 wherein said cells are mammalian cells.

5. The method according to claim 4 wherein said cells are cells of an isolated organ.

6. The method according to claim 4 wherein said cells are cells of an organ transplant.

7. A method of treating a patient suffering from a condition that results from or that is exacerbated by oxidant-induced toxicity comprising administering to said patient an effective amount of a compound of formula

8. The method according to claim 7 wherein said compound is complexed with a metal selected from the group consisting of manganese, iron, copper, cobalt, nickel or zinc.

9. The method according to claim 8 wherein said compound is complexed with manganese.