Illuminator for photodynamic therapy

• US 7,190,109 B2
• Filed: 01/13/2004
• Issued: 03/13/2007
• Est. Priority Date: 05/01/1998
• Status: Expired due to Fees

• Current Assignee: Dusa Pharmaceuticals (Sun Pharmaceutical Industries Limited)
• Original Assignee: Dusa Pharmaceuticals (Sun Pharmaceutical Industries Limited)
• Inventors: Lundahl, Scott, Carroll, Ronald, Kozodoy, Rebecca, Leppelmeier, Elton
• Primary Examiner(s): Williams; Joseph
• Application Number:
  US10/755,318
• Publication Number:
  US 20040143308A1
• Time in Patent Office: 1,155 Days
• Field of Search: 313485-487, 313/493, 313/634, 313/635, 313/317, 607 88- 94
• US Class Current: 313/485
• CPC Class Codes: A61B 2017/00057 Light
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61N 2005/0642 Irradiating part of the body at a certain distance
• CPC Class Codes: A61N 2005/0655 Tubes
• CPC Class Codes: A61N 5/0616 Skin treatment other than tanning
• CPC Class Codes: A61N 5/0617 Hair treatment
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

An apparatus and method for photodynamic therapy or photodynamic diagnosis using an illuminator comprising a plurality of light sources generally conforming to a contoured surface and irradiating the contoured surface with substantially uniform intensity visible light. The light sources may comprise generally U-shaped fluorescent tubes that are driven by electronic ballasts. Adjustment of the ballast voltage controls the output power of the tubes. The tubes are supported by a sheet-metal or plastic housing and are covered by a polycarbonate shield which directs cooling airflow within the unit and prevents glass-patient contact in the event of tube breakage. An aluminum reflector located behind the tubes increases both the output irradiance and the uniformity of the output distribution. The spacing of the U-shaped tubes is varied to increase the output at the edges of the illuminator to make the output more uniform. Also, different portions of the tubes are cooled at different amounts, to improve uniformity. A light sensor monitors output from the U-shaped tubes to provide a signal for adjusting the output from the tubes.

Claims

1. An illuminator for treating or diagnosing a patient, comprising:

at least one light source, comprising a phosphor which emits light in the blue region, configured to illuminate the patient to treat or diagnose a dermatological condition, wherein the spectral output of the at least one light source substantially matches the absorption spectrum of protoporphyrin IX.

2. An illuminator as set forth in claim 1, wherein the at least one light source has a peak wavelength near 417 nm.

3. An illuminator as set forth in claim 1, wherein the light source comprises a fluorescent lamp.

4. An illuminator for treating or diagnosing a patient, comprising:

at least one light source, comprising a phosphor which emits light in the blue region, configured to illuminate the patient to treat or diagnose a dermatological condition, wherein the light is substantially entirely limited to the blue region of the spectrum, wherein the spectral output of the at least one light source substantially matches the absorption spectrum of protoporphyrin IX.

5. An illuminator as set forth in claim 4, wherein the at least one light source has a peak wavelength near 417 nm.

6. An ilhuninator as set forth in claim 4, wherein the light source comprises a fluorescent lamp.

7. An illuminator for treating or diagnosing a patient, comprising:

at least one light source, comprising a Europium doped phosphor, configured to illuminate the patient to treat or diagnose a dermatological condition, wherein the spectral output of the at least one light source substantially matches the absorption spectrum of protoporphyrin IX.

8. An illuminator as set forth in claim 7, wherein the Europium doped phosphor comprises a Europium doped Strontium phosphate.

9. An illuminator as set forth in claim 7, wherein the Europium doped phosphor comprises Sr₂P₂O₇:

Eu.

10. An illuminator as set forth in claim 7, wherein the at least one light source has a peak wavelength near 417 nm.

11. An illuminator as set forth in claim 7, wherein the light source comprises a fluorescent lamp.

12. An illuminator for treating or diagnosing a patient, comprising:

at least one light source, comprising a Europium doped phosphor;

configured to illuminate the patient to treat or diagnose a dermatological condition,

wherein the light source is configured to illuminate the patient with substantially uniform intensity blue light, wherein the spectral output of the at least one light source substantially matches the absorption spectrum of protoporphyrin IX.

13. An illuminator for treating or diagnosing a patient, comprising:

at least one light source, comprising a Europium doped phosphor, configured to illuminate the patient to treat or diagnose a dermatological condition,

wherein at least part of the at least one light source is a curved tube, wherein the spectral output of the at least one light source substantially matches the absorption spectrum of protoporphyrin IX.