Patient specific circulation model
First Claim
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1. A method of modeling circulation in a living subject, such method comprising the steps of:
- simulating the fluid dynamics of an arterial network, wherein the simulation models blood flow through a plurality of arterial segments including one or more terminal efferent vessels;
adapting the simulation to substantially conform to a specific arterial anatomy of the living subject;
forcing the simulation with a forcing function made up of one or more flow-time or pressure-time signatures;
calculating a blood flows in the arterial network based upon the forced simulation;
measuring a blood flow in the living subject;
correcting the simulation based on the measured and calculated blood flows;
modifying the simulation to model a particular interventional procedure; and
,calculating a post-procedure blood flow in a selected arterial segment using the modified simulation in order to predict an outcome of the actual interventional procedure performed in the living subject.
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Abstract
A method and apparatus are provided for modeling circulation in a living subject. The method includes the steps of developing a model for living subjects in general and correcting the model to substantially conform to the overall cerebral physiology of the living subject. The method further includes the step of calculating a cerebral flow of the living subject based upon the corrected model and a selected cerebral blood flow perturbation.
154 Citations
30 Claims
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1. A method of modeling circulation in a living subject, such method comprising the steps of:
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simulating the fluid dynamics of an arterial network, wherein the simulation models blood flow through a plurality of arterial segments including one or more terminal efferent vessels; adapting the simulation to substantially conform to a specific arterial anatomy of the living subject; forcing the simulation with a forcing function made up of one or more flow-time or pressure-time signatures; calculating a blood flows in the arterial network based upon the forced simulation; measuring a blood flow in the living subject; correcting the simulation based on the measured and calculated blood flows; modifying the simulation to model a particular interventional procedure; and
,calculating a post-procedure blood flow in a selected arterial segment using the modified simulation in order to predict an outcome of the actual interventional procedure performed in the living subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 18, 19, 21, 22, 23, 24, 25)
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9. Apparatus for modeling circulation within a living subject, such apparatus comprising:
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a computerized model of an arterial network made up of a plurality of arterial segments including one or more terminal efferent vessels, wherein the apparatus includes means for calculating blood flows in the arterial network when the model is forced with a forcing function; means for adapting the model of the arterial network to substantially conform to a specific arterial anatomy of the living subject; means for measuring a blood flow in the living subject; means for correcting the model based upon the calculated and measured flows; means for modifying the model to reflect a particular interventional procedure; and
,means for calculating a post-procedure blood flow in a selected arterial segment using the modified model in order to predict an outcome of the actual interventional procedure performed in the living subject. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 20)
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26. A system for modeling circulation within a living subject, comprising:
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a computerized model of an arterial network made up of a plurality of arterial segments including one or more terminal efferent vessels, wherein the system includes means for calculating blood flows in the arterial network when the model is forced with a forcing function; means for adapting the model of the arterial network to substantially conform to a specific arterial anatomy of the living subject; wherein the arterial network is divided into a plurality of sectors, wherein each sector is terminated by a terminal efferent vessel and has a primary input vessel, and further wherein the terminal efferent vessels are modeled as terminal efferent resistances; means for measuring blood flows in the living subject corresponding to the primary input flows of the sectors; and means for adjusting the terminal efferent resistances for each sector in a manner which tends to make the calculated flow in the terminal efferent vessel match the measured primary input flow for each such sector. - View Dependent Claims (27, 28, 29, 30)
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Specification