Method of using platelet contractile force and whole blood clot elastic modulus as clinical markers

• US 7,192,726 B1
• Filed: 08/11/2000
• Issued: 03/20/2007
• Est. Priority Date: 08/13/1999
• Status: Expired due to Fees

• Current Assignee: Hemodyne, Inc.
• Original Assignee: Hemodyne, Inc.
• Inventors: Carr, Marcus E. Jr., Martin, Erika, Krischnaswami, Ashok
• Primary Examiner(s): GITOMER, RALPH J
• Application Number:
  US10/049,374
• Time in Patent Office: 2,412 Days
• Field of Search: 435/13, 435/4, 435/2
• US Class Current: 435/13
• CPC Class Codes: G01N 2800/224 Haemostasis or coagulation
• CPC Class Codes: G01N 2800/226 Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis
• CPC Class Codes: G01N 2800/323 Arteriosclerosis, Stenosis
• CPC Class Codes: G01N 2800/52 Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
• CPC Class Codes: G01N 33/86 involving blood coagulating time or factors, or their receptors

Abstract

Platelet contractile force and/or clot elastic modulus measurements are used to identify patients at risk for atherosclerosis or for bleeding during surgical procedures or other applications. Measurements which are elevated are indicative of atherosclerosis, and measurements which are reduced are indicative of a bleeding risk.

Claims

1. A method of monitoring treatment or therapy of a patient suffering from unstable angina or myocardial infarction, comprising the steps of:

obtaining a baseline measurement on a blood sample taken from said patient selected from the group consisting of platelet contractile force and clot elastic modulus;

providing said patient with treatment or therapy;

obtaining a measurement on a blood sample taken after said step of providing, said measurement being selected from the group consisting of platelet contractile force and clot elastic modulus; and

comparing said measurement and said baseline measurement, wherein progress of said treatment or therapy is indicated by a decline in said measurement relative to said baseline measurement.

2. The method of claim 1 wherein said measurement and said baseline measurement both provide platelet contractile force values.

3. The method of claim 1 wherein said measurement and said baseline measurement both provide clot elastic modulus values.

4. The method of claim 1, wherein the patient suffers from unstable angina.

5. The method of claim 1, wherein the patient suffers from myocardial infarction.

6. The method of claim 1, wherein the measurements are a force per platelet (FPP) parameter.