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Nucleic acid molecules encoding cytotoxic conjugates that contain a chemokine receptor targeting agent

  • US 7,192,736 B2
  • Filed: 02/22/2001
  • Issued: 03/20/2007
  • Est. Priority Date: 07/22/1998
  • Status: Expired due to Fees
First Claim
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1. A nucleic acid molecule, comprising a sequence of nucleotides encoding a conjugate that comprises a toxin and a chemokine receptor targeting agent, or a portion thereof sufficient for binding to a chemokine receptor and internalization of the chemokine receptor targeting agent, wherein:

  • the conjugate binds to a chemokine receptor resulting in internalization of the toxin in cells bearing the receptor; and

    the receptor occurs on activated immune cells.

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