Medication injector apparatus with drive assembly that facilitates reset

• US 7,195,616 B2
• Filed: 05/08/2002
• Issued: 03/27/2007
• Est. Priority Date: 05/16/2001
• Status: Expired due to Term

• Current Assignee: Eli Lilly and Company
• Original Assignee: Eli Lilly and Company
• Inventors: Madland, Steven Michael, Diller, Mark Gerard
• Primary Examiner(s): Sirmons; Kevin C.
• Assistant Examiner(s): GILBERT, ANDREW M
• Application Number:
  US10/477,781
• Publication Number:
  US 20040210199A1
• Time in Patent Office: 1,784 Days
• Field of Search: 604207-211, 604/218, 604/221, 604/224
• US Class Current: 604/224
• CPC Class Codes: A61B 2017/00482 with a code
• CPC Class Codes: A61M 2005/2407 from the rear
• CPC Class Codes: A61M 2005/2488 via rotation, e.g. threads or bayonet
• CPC Class Codes: A61M 2005/3125 specific display means, e.g. to indicate dose setting
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2205/583 by visual feedback
• CPC Class Codes: A61M 2205/585 having magnification means, e.g. magnifying glasses
• CPC Class Codes: A61M 2205/60 with identification means
• CPC Class Codes: A61M 2205/6027 Electric-conductive bridges closing detection circuits, with or without identifying elements, e.g. resistances, zener-diodes
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/3129 Syringe barrels A61M5/3205 and A61M5/50 take precedence
• CPC Class Codes: A61M 5/31535 Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
• CPC Class Codes: A61M 5/31543 piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
• CPC Class Codes: A61M 5/31551 including axial movement of dose setting member
• CPC Class Codes: A61M 5/31556 Accuracy improving means
• CPC Class Codes: A61M 5/31558 using scaling up or down transmissions, e.g. gearbox
• CPC Class Codes: A61M 5/31566 Means improving security or handling thereof
• CPC Class Codes: A61M 5/31568 Means keeping track of the total dose administered, e.g. since the cartridge was inserted
• CPC Class Codes: A61M 5/31573 Accuracy improving means
• CPC Class Codes: A61M 5/31575 : using scaling up or down transmissions, e.g. gearbox
• CPC Class Codes: A61M 5/31585 : performed by axially moving actuator, e.g. an injection button
• CPC Class Codes: A61M 5/31593 : Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
• CPC Class Codes: G01D 5/2497 : Absolute encoders G01D5/2454 takes precedence
• CPC Class Codes: G01D 5/25 : Selecting one or more conductors or channels from a plurality of conductors or channels, e.g. by closing contacts

Abstract

A medication injector apparatus such as an injection pen. The injection pen includes a resettable, cartridge plunger drive assembly including an axially floating nut, a cartridge plunger engaging screw, and a drive clutch movable with the nut and which when rotated causes the screw to screw through the nut. When a cartridge assembly is mounted to the pen base, the floating nut and drive clutch are shifted proximally such that the drive clutch is in torque transmitting engagement with a rotatable drive member of the pen, such that rotation of that drive member results in drive screw advancement through the nut in the distal direction. When the cartridge assembly is not mounted to the pen base, the floating nut and drive clutch are biased distally to disengage the drive clutch from torque transmitting engagement with the rotatable drive member and to thereby allow the drive screw to be reset proximally through the nut to a position more retracted within the pen base. The injection pen also may include an injection clicker assembly having a collar arranged coaxially on a drive sleeve and which oscillates axially on the drive sleeve that rotates during medication dispensing to provide an audible clicking sound that indicates injecting use of the pen. The injection pen also may include a doseable quantity identifier that uses a rotational matrix and a sensor for electrically sensing the arrangement of the dose setting mechanism of the pen, which identifier may be part of a therapeutic dose indicating system that utilizes a cartridge recognizer to recognize a concentration of medication so as to allow an automatic determination of a therapeutic dose. The injection pen further may include an assembly for selectively rotating a drive sleeve of the pen, which assembly has a dial that rotates out during dose setting and which translates in without rotation during dose injecting.

Claims

1. A resettable, cartridge plunger drive assembly of a dose injecting mechanism of a medication injector apparatus, the apparatus including a reusable base and a cartridge assembly mountable to the base, the base having a rotatable drive member of the dose injecting mechanism within a base housing, the cartridge assembly having a medicine-filled cartridge with a movable plunger at one end and an outlet at the other end, the drive assembly comprising:

a nut keyed to the base housing to be both movable relative thereto between first and second axial positions, and rotatably fixed relative thereto at said first and second axial positions, said nut including an internally threaded opening;

a screw including a plunger-engaging distal end and external threading in threaded engagement with said internally threaded opening of said nut;

a drive clutch connected to said nut to be axially retained and rotatably movable relative thereto, said drive clutch keyed to said screw to be rotatably fixed and axially movable relative thereto;

said nut positioned within the base housing to be axially movable from said first axial position to said second axial position by engagement with the cartridge assembly during mounting of the cartridge assembly to the reusable base, wherein said drive clutch is in torque transmitting engagement with the rotatable drive member when said nut is disposed in said second axial position, whereby rotation of the drive member during operation of the dose injecting mechanism rotates said drive clutch and thereby said screw to produce axial movement of said screw in a distal direction through said nut to thereby advance the plunger-engaging distal end of said screw to force medication from the cartridge outlet; and

a biasing element that biases said nut from said second axial position toward said first axial position when the cartridge assembly is not mounted to the reusable base, wherein said drive clutch is disengaged from torque transmitting engagement with the rotatable drive member when said nut is disposed in said first axial position, whereby application of a force in a proximal direction on said plunger-engaging distal end of said screw axially moves said screw in a proximal direction as it screws through said nut to thereby reset said screw.

2. The resettable, cartridge plunger drive assembly of claim 1 wherein said nut is keyed to the base housing by a plurality of radially outwardly extending keys angularly spaced around the periphery of the nut which insert within axially extending grooves defined by the base housing.

3. The resettable, cartridge plunger drive assembly of claim 1 wherein said drive clutch is connected to said nut by at least one radially inwardly projecting rim of said nut which latches a projecting ring portion of said drive clutch.

4. The resettable, cartridge plunger drive assembly of claim 1 wherein said screw extends through a central opening of said drive clutch having at least one inwardly extending key, and wherein said drive clutch is keyed to said screw by said at least one key of said drive clutch inserting within at least one axially extending keyway channel formed in an outer radial periphery of said screw.

5. The resettable, cartridge plunger drive assembly of claim 4 wherein said at least one inwardly extending key includes first and second keys diametrically arranged within the drive clutch central opening, and wherein the at least one keyway channel includes first and second channels located on opposite sides of said screw.

6. The resettable, cartridge plunger drive assembly of claim 1 wherein said biasing element comprises a compression spring having a first end abutting said nut and a second end abutting a shoulder of the housing.

7. The resettable, cartridge plunger drive assembly of claim 1 wherein said nut has a distal surface that directly abuts the cartridge assembly during mounting of the cartridge assembly to the reusable base, said distal surface being axially recessed within the base housing when said nut is located at said first and second axial positions.

8. The resettable, cartridge plunger drive assembly of claim 1 wherein said drive clutch includes axially projecting teeth that mate with complementary teeth on the rotatable drive member.

9. The resettable, cartridge plunger drive assembly of claim 1 wherein a portion of the cartridge assembly which engages said nut to axially move said nut during mounting of the cartridge assembly to the reusable base comprises a rearward end of a cartridge housing element which is sealingly engaged by the movable plunger.

10. A resettable, cartridge plunger drive assembly of a dose injecting mechanism of a medication injector apparatus, the apparatus including a reusable base and a cartridge assembly mountable to the base, the base having a rotatable drive member of the dose injecting mechanism within a base housing, the cartridge assembly having a medicine-filled cartridge with a movable plunger at one end and an outlet at the other end, the drive assembly comprising:

a nut keyed to the base housing to be both movable relative thereto between first and second axial positions, and rotatably fixed relative thereto at said first and second axial positions, said nut including an internally threaded opening;

a screw including a plunger-engaging distal end and external threading in threaded engagement with said internally threaded opening of said nut;

a drive clutch keyed to said screw to be rotatably fixed and axially movable relative thereto;

said nut positioned within the base housing to be axially movable from said first axial position to said second axial position by engagement with the cartridge assembly during mounting of the cartridge assembly to the reusable base;

said drive clutch structured and arranged to be shifted from a location out of torque transmitting engagement with the rotatable drive member to a location in torque transmitting engagement with the rotatable drive member when said nut is moved from said first axial position to said second axial position, wherein when said drive clutch is in torque transmitting engagement with the rotatable drive member, rotation of the drive member during operation of the dose injecting mechanism rotates said drive clutch and thereby said screw to produce axial movement of said screw in a distal direction through said nut to thereby advance the plunger-engaging distal end of said screw to force medication from the cartridge outlet; and

a biasing element structured and arranged to bias said drive clutch from said location in torque transmitting engagement with the rotatable drive member to said location out of torque transmitting engagement with the rotatable drive member, and thereby move said nut from said second axial position toward said first axial position, when the cartridge is not mounted to the reusable base, wherein when said drive clutch is out of torque transmitting engagement with the rotatable drive member, application of a force in a proximal direction on said plunger-engaging distal end of said screw axially moves said screw in a proximal direction as it screws through said nut to thereby reset said screw.