Sensor membrane, a method for the preparation thereof, a sensor and a layered membrane structure for such sensor
First Claim
1. A sensor membrane comprising, in admixture, at least one polymer material, at least one hydrophilic compound, which is selected from the group consisting of polyethylene (2-8) glycol and polypropylene (2-3) glycol, and at least one surfactant, which has a hydrophilic-lipophilic balance (HLB) value less than 10 and which is selected from the group consisting of polyethylene glycol fatty acid esters and polyethylene glycol ethers.
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Abstract
A membrane for a sensor, a method for the preparation thereof, a layered membrane structure and a sensor for analytical measurements which require controlled analyte permeability. The membrane, layered structure and sensor may be used for biological, physiological and chemical measurements, however, are especially applicable for electrochemical measurements of glucose, lactate, urea and creatinine. The membrane comprises at least one polymer material, at least one surfactant, and at least one hydrophilic compound in admixture to provide a membrane structure in which micelles of hydrophilic compound lined with thin layers of surfactant are randomly distributed in the bulk polymer of the membrane. Upon conditioning of the membrane a structure of a perculating network of pores lined with surfactant is formed which has excellent permeability properties. The membrane has the additional advantage of a proper adhesion to polymer encapsulant structures. The membrane is prepared from a mixture of at least one polymer material, at least one surfactant, at least one hydrophilic compound and at least one solvent.
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Citations
64 Claims
- 1. A sensor membrane comprising, in admixture, at least one polymer material, at least one hydrophilic compound, which is selected from the group consisting of polyethylene (2-8) glycol and polypropylene (2-3) glycol, and at least one surfactant, which has a hydrophilic-lipophilic balance (HLB) value less than 10 and which is selected from the group consisting of polyethylene glycol fatty acid esters and polyethylene glycol ethers.
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30. A method for the preparation of a sensor membrane comprising the steps of:
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mixing at least one polymer material, at least one surfactant, at least one hydrophilic compound, which is selected from the group consisting of polyethylene (2-8) glycol and polypropylene (2-3) glycol, and at least one solvent in which the at least one polymer material is soluble applying said mixture onto a substrate, and evaporating the solvent wherein the at least one surfactant has a hydrophilic-lipophilic balance (HLB) value less than 10 and is selected from the group consisting of polyethylene cilycol fatty acid esters and polyethylene cilycol ethers. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
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49. A layered membrane structure for a sensor comprising a first membrane, an enzyme layer and a second membrane in which the said first membrane is prepared by a method comprising the steps of:
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mixing at least one polymer material, at least one surfactant, at least one hydrophilic compound, which is selected from the group consisting of polyethylene (2-8) glycol and polypropylene (2-3) glycol, and at least one solvent in which the at least one polymer material is soluble applying said mixture onto a substrate, and evaporating the solvent wherein the at least one surfactant has a hydrophilic-lipophilic balance (HLB) value less than 10 and is selected from the group consisting of polyethylene glycol fatty acid esters and polyethylene glycol ethers. - View Dependent Claims (50, 51, 52, 53, 54, 55, 56, 57)
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58. A sensor comprising a first membrane, an enzyme layer, and at least one electrode in which the said first membrane is a membrane prepared by a method comprising the steps of:
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mixing at least one polymer material, at least one surfactant, at least one hydrophilic compound, which is selected from the group consisting of polyethylene (2-8) glycol and polypropylene (2-3) glycol, and at least one solvent in which the at least one polymer material is soluble applying said mixture onto a substrate, and evaporating the solvent wherein the at least one surfactant has a hydrophilic-lipophilic balance (HLB) value less than 10 and is selected from the group consisting of polyethylene glycol fatty acid esters and polyethylene glycol ethers. - View Dependent Claims (59, 60, 61, 62, 63)
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64. A sensor membrane comprising, in admixture, at least one polymer material, at least one hydrophilic compound, which is selected from the group consisting of diethylene glycol and triethylene glycol, and at least one surfactant, which has a hydrophilic-lipophilic balance (HLB) value less than 10 and which is selected from the group consisting of polyethylene glycol fatty acid esters and polyethylene glycol ethers.
Specification