Systems and methods using multiple solvents for the removal of lipids from fluids
First Claim
1. A device for removing at least one lipid from fluid containing lipids or lipid-containing organisms, comprising:
- at least one drip through column for contacting the fluid with a first extraction solvent, forming a first mixture comprising the fluid and the first extraction solvent, and dissolving at least a portion of the at least one lipid in the first extraction solvent;
a first solvent removal device for contacting the first mixture with a second extraction solvent, removing at least a portion of the first extraction solvent, and forming a second mixture comprising the first extraction solvent, the second extraction solvent and the fluid; and
a second solvent removal device for removing at least a portion of the second extraction solvent from the second mixture.
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Accused Products
Abstract
This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.
153 Citations
18 Claims
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1. A device for removing at least one lipid from fluid containing lipids or lipid-containing organisms, comprising:
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at least one drip through column for contacting the fluid with a first extraction solvent, forming a first mixture comprising the fluid and the first extraction solvent, and dissolving at least a portion of the at least one lipid in the first extraction solvent; a first solvent removal device for contacting the first mixture with a second extraction solvent, removing at least a portion of the first extraction solvent, and forming a second mixture comprising the first extraction solvent, the second extraction solvent and the fluid; and a second solvent removal device for removing at least a portion of the second extraction solvent from the second mixture. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A device for removing at least one lipid from fluid containing lipids or lipid-containing organisms, comprising:
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a device for contacting the fluid with a first extraction solvent, forming a first mixture comprising the fluid and the first extraction solvent, and dissolving at least a portion of the at least one lipid in the first extraction solvent; at least one drip through column for contacting the first mixture with a second extraction solvent, removing at least a portion of the first extraction solvent, and forming a second mixture comprising the first extraction solvent, the second extraction solvent and the fluid; and a solvent removal device for removing at least a portion of the second extraction solvent from the second mixture. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15)
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16. A device for removing at least one lipid from fluid containing lipids or lipid-containing organisms, comprising:
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at least one drip through column for contacting the fluid with a first extraction solvent, forming a first mixture comprising the fluid and the first extraction solvent, and dissolving at least a portion of the at least one lipid in the first extraction solvent, and for contacting the first mixture with a second extraction solvent, removing at least a portion of the first extraction solvent, and forming a second mixture comprising the first extraction solvent, the second extraction solvent and the fluid; and a solvent removal device for removing at least a portion of the second extraction solvent from the second mixture, the solvent removal device comprising at least one hollow fiber contactor. - View Dependent Claims (17, 18)
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Specification