Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
First Claim
1. An isolated HCV polynucleic acid of a clade 6 type 13 HCV genotype, said polynucleic acid characterized in that it is comprising(i) a 5′
- UTR nucleic acid sequence defined by SEQ ID NO;
1, or(ii) the complement of the nucleic acid sequence of (i);
and wherein said polynucleic acid is RNA, DNA, cDNA or a synthetic polynucleic acid.
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Abstract
The present invention relates to genomic nucleotide sequences and amino acid sequences corresponding to the non-coding and coding region of a new type of HCV. The invention relates to new HCV types and subtypes sequences which are different from the known HCV types and subtypes sequences. Particularly, the present invention relates to said new HCV type sequences; a process for preparing them, and their use for diagnosis, prophylaxis and therapy. More particularly, the present invention provides new type-specific sequences of the 5′ NCR, Core, the E1 and the NS5 regions of the new HCV type. These new HCV sequences are useful to diagnose the presence of HCV type genotypes or serotypes in a biological sample. Moreover, the availability of these new type-specific sequences can increase the overall sensitivity of HCV detection and should also prove to be useful for prophylactic and therapeutic purposes.
29 Citations
27 Claims
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1. An isolated HCV polynucleic acid of a clade 6 type 13 HCV genotype, said polynucleic acid characterized in that it is comprising
(i) a 5′ - UTR nucleic acid sequence defined by SEQ ID NO;
1, or(ii) the complement of the nucleic acid sequence of (i); and wherein said polynucleic acid is RNA, DNA, cDNA or a synthetic polynucleic acid. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 27)
- UTR nucleic acid sequence defined by SEQ ID NO;
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2. An isolated oligonucleotide comprising at least 65 contiguous nucleotides taken from the HCV polynucleic acid defined by SEQ ID NO:
- 1 or the complement thereof, and comprising, relative to the start codon of the HCV polyprotein coding sequence, an adenine nucleotide at position −
159. - View Dependent Claims (4, 5, 6, 7, 8, 22, 23, 24, 25, 26)
- 1 or the complement thereof, and comprising, relative to the start codon of the HCV polyprotein coding sequence, an adenine nucleotide at position −
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3. An isolated oligonucleotide consisting of at least 65 contiguous nucleotides taken from the HCV polynucleic acid defined by SEQ ID NO:
- 1 or the complement thereof, and comprising, relative to the start codon of the HCV polyprotein coding sequence, an adenine nucleotide at position −
159.
- 1 or the complement thereof, and comprising, relative to the start codon of the HCV polyprotein coding sequence, an adenine nucleotide at position −
Specification