Applicator for dispensing bioactive compositions and methods for using the same
First Claim
1. An applicator for delivering two or more different bioactive compositions, comprising:
- an inkjet dispenser comprising multiple ejector heads, each of which is in fluid communication with an orifice adapted for high-speed ejection of droplets from the dispenser, the inkjet dispenser further including a main body;
multiple replaceable fluid reservoirs, each of which is configured to hold and to simultaneously deliver one of the bioactive compositions to a respective one of the multiple ejector heads for ejection therethrough, the replaceable fluid reservoirs at least partially insertable through the body, and each of the multiple reservoirs configured to hold a different bioactive composition; and
a body orifice spacer adapted to be positioned between the dispenser orifice and a target during ejection of the bioactive composition to the target.
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Accused Products
Abstract
Bioactive agents are topically administered or delivered to a mucous membrane by a jet dispenser using inkjet technology, such as that used in printing. The dispenser propels precise volumes of droplets or powder for administration to a subject, such as being inhaled through the mouth or nose. A controller in the dispenser may control delivery of multiple different drugs, timing of drug administration, or change drug regimens in response to a changing medical condition of a patient, such as those monitored by a sensor in communication with the controller, for example to prevent an overdose. Administration methods are also provided, along with replacement kits.
167 Citations
52 Claims
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1. An applicator for delivering two or more different bioactive compositions, comprising:
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an inkjet dispenser comprising multiple ejector heads, each of which is in fluid communication with an orifice adapted for high-speed ejection of droplets from the dispenser, the inkjet dispenser further including a main body; multiple replaceable fluid reservoirs, each of which is configured to hold and to simultaneously deliver one of the bioactive compositions to a respective one of the multiple ejector heads for ejection therethrough, the replaceable fluid reservoirs at least partially insertable through the body, and each of the multiple reservoirs configured to hold a different bioactive composition; and a body orifice spacer adapted to be positioned between the dispenser orifice and a target during ejection of the bioactive composition to the target. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. An applicator for delivering three or more different bioactive compositions, comprising:
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an inkjet dispenser comprising at least three fluid ejection heads, each ejection head further comprising a dispenser orifice; multiple containers configured for holding and simultaneously delivering one of the bioactive compositions to a respective one of the at least three ejection heads, each container holding a different bioactive composition and operably coupled to each fluid ejection head by an independent conduit; and a body orifice spacer positioned between the fluid ejection heads and a target during ejection of the bioactive composition to the target. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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28. An applicator for delivering two or more different bioactive compositions, comprising:
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an inkjet dispenser comprising multiple ejector heads, each of which is in fluid communication with an orifice through which droplets are ejected in an ejection direction at high speed; multiple containers, each of which is configured for holding and substantially simultaneously delivering one of the bioactive compositions to a respective one of the multiple ejector heads for ejection therethrough, each of the multiple containers configured to hold a different bioactive composition; and a delivery device that changes a delivery pathway of the droplets from the ejection direction to a delivery direction. - View Dependent Claims (29, 30, 31)
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32. An applicator for delivering two or more different bioactive compositions to a mucous membrane, comprising:
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an inkjet dispenser comprising multiple ejector heads, each of which is in fluid communication with an orifice, the orifice capable of ejecting the bioactive compositions therethrough; a first container configured to hold one of the bioactive compositions and operably coupled to the dispenser; a second container configured to hold an other of the bioactive compositions and operably coupled to the dispenser; a processor electrically connected to the jet dispenser, programmed to simultaneously or sequentially deliver selected dosages of the bioactive compositions, and configurable to adjust a dispensed ratio of one bioactive composition to an other bioactive composition; and an input slot for removable memory electrically connected to the processor. - View Dependent Claims (33, 34, 35, 36, 37)
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38. A kit for administering two or more different bioactive compositions to a subject, comprising:
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an applicator, comprising an inkjet dispenser comprising multiple ejector heads, each of which is in fluid communication with an orifice for high-speed ejection of droplets from the dispenser, multiple replaceable fluid reservoirs, each of which is configured to hold and simultaneously deliver one of the bioactive compositions to a respective one of the multiple ejector heads for ejection therethrough, each of the multiple reservoirs configured to hold a different bioactive composition, and a separate body orifice spacer capable of being positioned between the dispenser orifice and the subject during ejection of the bioactive compositions to the subject; and an electronic programmable controller operable to actuate the inkjet dispenser. - View Dependent Claims (39, 40, 41, 42, 43)
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44. A method for administering two or more different bioactive compositions to a subject, comprising:
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providing an inkjet dispenser operatively connected to a programmable controller, the inkjet dispenser comprising a plurality of reservoirs, each of which is fluidly connected to an ejector head, each of the reservoirs is configured to contain a different bioactive substance, and each of the ejector heads is configured to dispense one of the different bioactive substances;
wherein the reservoirs are cartridges capable of being removed and replaced through an opening in the dispenser;simultaneously dispensing the bioactive compositions from the containers through the jet dispenser into a mouth or nose; and removing one of the reservoirs.
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45. A method for administering two or more different bioactive compositions to a subject, comprising:
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applying to a body orifice of the subject a body orifice spacer of an applicator, the applicator comprising a main body, a controller, and an inkjet dispenser having multiple ejector heads, each of which has a dispenser orifice through which droplets of the bioactive compositions are ejected, the applicator further comprising multiple containers configured to hold and simultaneously deliver one of the bioactive compositions to a respective one of the multiple ejector heads, wherein each of the multiple containers is configured to hold a different bioactive composition and wherein the spacer extends substantially transverse to the main body; simultaneously dispensing the bioactive compositions from the dispenser toward the body orifice. - View Dependent Claims (46, 47, 48, 49, 50, 51, 52)
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Specification