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Non-invasive measurement of pH

  • US 7,198,756 B2
  • Filed: 07/11/2002
  • Issued: 04/03/2007
  • Est. Priority Date: 07/11/2002
  • Status: Expired due to Fees
First Claim
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1. A system for measuring pH in a medium, comprising:

  • a light source for optically exciting the medium;

    a detection unit to detect a first optical signal from a fluorescent biomolecule in the medium whose fluorescence is dependent on the pH of the medium and to detect a second optical signal from a marker in the medium whose fluorescence is substantially independent of pH of the medium wherein the detection unit includes a wavelength light separator to separate light received from the medium into the first optical signal received from the fluorescent biomolecule and the second optical signal, and also includes respective first and second photodetectors to detect the first and second optical signals; and

    a controller coupled to receive detection signals from the detection unit related to the first and second optical signals, the controller configured to determine the medium pH based on the first and second optical signals.

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