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Formulations for transdermal or transmucosal application

  • US 7,198,801 B2
  • Filed: 03/10/2004
  • Issued: 04/03/2007
  • Est. Priority Date: 08/03/2000
  • Status: Expired due to Term
First Claim
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1. A formulation for transdermal or transmucosal administration of an active agent, the formulation comprising:

  • at least one active agent, provided that when the active agent is estrogen, a progestin is not present in the formulation, and when the active agent is progestin, estrogen is not present in the formulation; and

    a delivery vehicle comprising a C2 to C4 alkanol, a polyalcohol, and a permeation enhancer of monoalkyl ether of diethylene glycol present in an amount sufficient to provide permeation enhancement of the active agent through dermal or mucosal surfaces;

    wherein the formulation is substantially free of long-chain fatty alcohols, long-chain fatty acids, and long-chain fatty esters in order to avoid undesirable odor and irritation effects caused by such compounds during use of the formulation.

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