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Methods of surface modification of a flexible substrate to enhance cell adhesion

  • US 7,198,855 B2
  • Filed: 09/12/2003
  • Issued: 04/03/2007
  • Est. Priority Date: 09/12/2003
  • Status: Expired due to Term
First Claim
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1. A method for producing a surface with enhanced cell-adhesive properties, comprising:

  • a. applying a stress to a flexible polymeric matrix wherein said polymeric matrix comprises chemical sensor particles dispersed in said matrix, said particles conferring chemical sensing capability;

    b. maintaining said flexible polymeric matrix as a strained matrix;

    c. modifying the surface of said strained matrix by grafting a self-assembled monolayer onto said strained matrix, said self-assembled monolayer comprising at least one exposed functional group;

    d. activating said at least one functional group of said self-assembled monolayer; and

    e. coupling at least one cell-adhesive molecule to said at least one activated functional group on said self-assembled monolayer.

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