Methods of surface modification of a flexible substrate to enhance cell adhesion
First Claim
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1. A method for producing a surface with enhanced cell-adhesive properties, comprising:
- a. applying a stress to a flexible polymeric matrix wherein said polymeric matrix comprises chemical sensor particles dispersed in said matrix, said particles conferring chemical sensing capability;
b. maintaining said flexible polymeric matrix as a strained matrix;
c. modifying the surface of said strained matrix by grafting a self-assembled monolayer onto said strained matrix, said self-assembled monolayer comprising at least one exposed functional group;
d. activating said at least one functional group of said self-assembled monolayer; and
e. coupling at least one cell-adhesive molecule to said at least one activated functional group on said self-assembled monolayer.
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Abstract
The present invention provides methods of producing a surface with enhanced cell-adhesive properties comprising applying a stress to a polymeric matrix. The strained matrix is then modified by grafting a self-assembled monolayer onto the strained matrix, with the self-assembled monolayer comprising at least one exposed functional group. At least one cell-adhesive molecule can then be coupled to the at least one exposed functional group on the self-assembled monolayer to produce a surface with enhanced cell-adhesive properties.
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Citations
35 Claims
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1. A method for producing a surface with enhanced cell-adhesive properties, comprising:
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a. applying a stress to a flexible polymeric matrix wherein said polymeric matrix comprises chemical sensor particles dispersed in said matrix, said particles conferring chemical sensing capability; b. maintaining said flexible polymeric matrix as a strained matrix; c. modifying the surface of said strained matrix by grafting a self-assembled monolayer onto said strained matrix, said self-assembled monolayer comprising at least one exposed functional group; d. activating said at least one functional group of said self-assembled monolayer; and e. coupling at least one cell-adhesive molecule to said at least one activated functional group on said self-assembled monolayer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A device comprising a surface, said surface comprising
a. a flexible polymer matrix, wherein said matrix comprises chemical sensor particles dispersed in said matrix, said particles conferring chemical sensing capability; -
b. a mechanically self-assembled monolayer; and c. at least one cell-adhesive molecule coupled to said mechanically self-assembled monolayer through at least one functional group on said self-assembled monolayer. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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Specification