Device and method for reducing inflammatory mediators in blood
First Claim
1. A method for down-regulating a patient'"'"'s immune system by removing one or more immune system mediators from the patient'"'"'s blood, comprising:
- obtaining blood from the patient;
diluting the blood with a diluent to reduce hematocrit, thereby producing diluted blood;
transporting substantially all of the diluted blood to a first filter at a flow rate of less than 400 ml/min;
extracting one or more first immune system mediators and diluent from the diluted blood using the first filter, thereby producing treated blood;
extracting one or more second immune system mediators from an output of the first filter comprising immune system mediators and diluent using a second filter; and
returning the treated blood to the patient.
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Accused Products
Abstract
A method and apparatus for preventing and treating septicemia in patient blood is provided. The extracorporeal system includes an antimicrobial device to inactivate at least 99% of bloodborne microorganisms, a hemoconcentrator/filtration unit to remove approximately 50–75% of target molecules from the patient blood and a filter unit to remove target molecules from patient blood from the sieved plasma filtrate. Target molecules are produced by microorganisms, as well as by the patient'"'"'s cells. These molecules include endotoxins from Gram negative bacteria, exotoxins from Gram negative and Gram positive bacteria, as well as RAP protein mediator from Staphylococcus aureus, and cell mediators such as tumor necrosis factor-alpha, and interleukin 1-beta, interleukin 6, complement proteins C3a and C5a, and bradykinin.
75 Citations
47 Claims
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1. A method for down-regulating a patient'"'"'s immune system by removing one or more immune system mediators from the patient'"'"'s blood, comprising:
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obtaining blood from the patient; diluting the blood with a diluent to reduce hematocrit, thereby producing diluted blood; transporting substantially all of the diluted blood to a first filter at a flow rate of less than 400 ml/min; extracting one or more first immune system mediators and diluent from the diluted blood using the first filter, thereby producing treated blood; extracting one or more second immune system mediators from an output of the first filter comprising immune system mediators and diluent using a second filter; and returning the treated blood to the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
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45. A system for down-regulating a patient'"'"'s immune system by removing one or more immune system mediators from the patient'"'"'s blood, comprising:
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apparatus for removing blood from the patient; a diluent source for supplying a diluent to the blood which has been removed from the patient for the purpose of diluting the blood and reducing the hematocrit thereof; a first filter means for receiving the substantially all of the diluted blood and extracting one or more immune system mediators and diluent therefrom, wherein the diluted blood is received by said first filter means at a combined flow rate of less than 400 ml/min; a second filter means for receiving the output from said first filter means including immune system mediators and diluent and extracting the immune system mediators therefrom; and a return path for returning a portion of the blood to the patient after the immune system mediators and diluent have been extracted therefrom by said first filter means. - View Dependent Claims (46, 47)
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Specification