Drug delivery system for implantable cardiac device
First Claim
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1. A drug delivery system comprising:
- an implantable cardiac device having incorporated therein a sensor for sensing a physiological variable in a patient, a first telemetry interface for transmitting radio frequency signals, and circuitry for modulating the radio frequency signals with a drug delivery command signal;
an external drug delivery device for affixation to a skin surface location on the patient, the drug delivery device having incorporated therein a second telemetry interface for receiving radio frequency signals, circuitry for demodulating radio signals to derive a drug delivery command signal therefrom, and circuitry for controlling the drug delivery device in order to deliver a drug upon receipt of a drug delivery command signal;
wherein the implantable cardiac device is programmed to transmit a drug delivery command signal to the external drug delivery device in response to the sensed physiological variable in a manner that attempts to control the sensed variable in a closed-loop fashion; and
,wherein the system is programmed to maintain a downloadable log of the sensed physiological variable and of the amount of drug administered by the drug delivery device that can be used to formulate an optimum drug dosage schedule for the patient.
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Abstract
A drug delivery system incorporated into a cardiac device for delivering a dose of a drug to a patient upon detection of a particular medical condition. The cardiac device may be, for example, an implantable cardioverter/defibrillator, cardiac pacemaker, or combination device that communicates via a radio frequency link with a drug delivery device. The drug delivery device is preferably an electrically modulated transdermal drug delivery device for delivering the drug transdermally in accordance with a signal received from the cardiac device.
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Citations
18 Claims
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1. A drug delivery system comprising:
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an implantable cardiac device having incorporated therein a sensor for sensing a physiological variable in a patient, a first telemetry interface for transmitting radio frequency signals, and circuitry for modulating the radio frequency signals with a drug delivery command signal; an external drug delivery device for affixation to a skin surface location on the patient, the drug delivery device having incorporated therein a second telemetry interface for receiving radio frequency signals, circuitry for demodulating radio signals to derive a drug delivery command signal therefrom, and circuitry for controlling the drug delivery device in order to deliver a drug upon receipt of a drug delivery command signal; wherein the implantable cardiac device is programmed to transmit a drug delivery command signal to the external drug delivery device in response to the sensed physiological variable in a manner that attempts to control the sensed variable in a closed-loop fashion; and
,wherein the system is programmed to maintain a downloadable log of the sensed physiological variable and of the amount of drug administered by the drug delivery device that can be used to formulate an optimum drug dosage schedule for the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for drug delivery comprising;
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sensing a physiological variable in a patient with an implantable cardiac device; generating a command signal with the implantable cardiac device in response to the sensed physiological variable in a manner that attempts to control the sensed variable in a closed-loop fashion; transmitting the command signal with the implantable cardiac device to an external drug delivery device affixed to a skin surface location on the patient via a radio telemetry link; receiving the command signal with the external drug delivery device; delivering a drug with the external drug delivery device based on the command signal; downloading a log of the sensed physiological variable and of the amount of drug administered by the drug delivery device; and
,using the downloaded log to formulate an optimum drug dosage schedule for the patient. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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Specification