Integrated solid-phase hydrophilic matrix circuits and micro-arrays
First Claim
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1. An enclosed hydrophilic matrix device for transport of an aqueous solute, comprisingan electrically insulated substrate;
- a hydrophilic matrix path on the substrate for electro-kinetic transport of the solute, the matrix path having a pair of spaced apart contacting locations for respective electric contact with a source of power for producing an electric potential along the hydrophilic matrix path;
an electrode supported on the substrate and having a contact end for connection to the power source and a matrix end for electric contact with the hydrophilic matrix at one of the contacting locations;
the hydrophilic matrix being initially dry and including a humectant for increasing a water absorption rate of the matrix;
an insulator enclosing the hydrophilic matrix for sealing the matrix between the insulator and the substrate, the insulator being made of a water vapor permeable material impermeable to the solute; and
an orifice in the insulator above the matrix for the passage of an aqueous solute through the insulator.
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Abstract
The invention is directed to analytical devices and micro-arrays with integral fluidic inputs and outputs. The devices are constructed from planar solid-phase hydrophilic matrix circuits containing dry chemical reagents overlaying integral electro-kinetic pumping electrodes. The hydrophilic matrix circuits are enclosed within a gas permeable electrical insulator. The devices are for use in micro-scale bio-analysis, mixture separation and reaction.
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Citations
55 Claims
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1. An enclosed hydrophilic matrix device for transport of an aqueous solute, comprising
an electrically insulated substrate; -
a hydrophilic matrix path on the substrate for electro-kinetic transport of the solute, the matrix path having a pair of spaced apart contacting locations for respective electric contact with a source of power for producing an electric potential along the hydrophilic matrix path; an electrode supported on the substrate and having a contact end for connection to the power source and a matrix end for electric contact with the hydrophilic matrix at one of the contacting locations; the hydrophilic matrix being initially dry and including a humectant for increasing a water absorption rate of the matrix; an insulator enclosing the hydrophilic matrix for sealing the matrix between the insulator and the substrate, the insulator being made of a water vapor permeable material impermeable to the solute; and an orifice in the insulator above the matrix for the passage of an aqueous solute through the insulator. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 51, 52, 53, 54, 55)
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38. A micro reactor device with integrated fluidic i/o, comprising
an insulated substrate; -
a pair of electrodes supported on the substrate, each electrode having a contact end for connection to an external circuit for supplying power and a matrix end for electric contact with a hydrophilic matrix; a hydrophilic matrix path on the substrate for electro-kinetic transport of the solute, the matrix path including a reservoir for containing a reagent, a transport path for electro-kinetic transport of the reagent, a discrete micro-reactor for carrying out a chemical reaction and a pair of spaced apart contacting locations for electric contact with the respective matrix ends of the electrodes, the matrix being initially dry and including a humectant for increasing a water absorption rate of the matrix; an insulator enclosing the hydrophilic matrix for sealing the matrix between the insulator and the substrate, the insulator being made of a vapor permeable material impermeable to the solute; and an orifice in the insulator above the matrix for the passage of an aqueous solute through the insulator. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50)
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Specification