Treatment of ungual and subungual diseases

• US 7,201,925 B2
• Filed: 02/02/2004
• Issued: 04/10/2007
• Est. Priority Date: 04/23/2002
• Status: Expired due to Fees

• Current Assignee: NUCRYST Pharmaceuticals Corp. (The Westaim Corporation)
• Original Assignee: Nueryst Pharmaceuticals Corporation
• Inventors: Gillis, Scott H.
• Primary Examiner(s): Pak; John
• Application Number:
  US10/770,132
• Publication Number:
  US 20040176312A1
• Time in Patent Office: 1,163 Days
• Field of Search: 424/405, 424/489, 424617-619, 424/646, 424/649, 514/492, 514/495, 514/858, 514/861, 514/863, 514/951, 604/68, 604/131, 604/140
• US Class Current: 424/618
• CPC Class Codes: A61K 31/28 Compounds containing heavy metals
• CPC Class Codes: A61K 31/496 Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• CPC Class Codes: A61K 31/704 attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin digitoxin A61K31/7048
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61K 47/36 Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• CPC Class Codes: A61K 47/38 Cellulose; Derivatives thereof
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0021 Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/06 Antipsoriatics
• CPC Class Codes: A61P 17/12 Keratolytics, e.g. wart or anti-corn preparations
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/10 Antimycotics

Abstract

The treatment of ungual and subungual diseases is disclosed.

Claims

1. A method for the treatment of an ungual or subungual disease of a subject, the method comprising:

administering via a needleless injector an effective ungual or subungual disease treating amount of a metal-containing material to an area of the subject associated with said disease, wherein the metal-containing material is an atomically disordered, nanocrystalline material that contains a metal selected from the group consisting of silver, gold, platinum and palladium.

2. The method of claim 1, wherein the disease is selected from the group consisting of onychomycosis, tinea unguim infection, and combinations thereof.

3. The method of claim 1, wherein the disease is selected from the group consisting of onychomycosis, tinea unguim infection, psoriasis of the unguis, eczema of the unguis, lichen planus of the unguis, viral warts of the unguis and combinations thereof.

4. The method of claim 1, wherein the disease is a subungual disease.

5. The method of claim 1, wherein the disease is an ungual disease.

6. The method of claim 1, wherein the area of the subject comprises an unguis.

7. The method of claim 6, wherein the subject is a human and the unguis is a toe nail.

8. The method of claim 6, wherein the subject is a human and the unguis is a finger nail.

9. The method of claim 1, wherein the area of the subject comprises tissue adjacent to an unguis of the subject.

10. The method of claim 9, wherein the tissue adjacent to the unguis of the subject comprises skin.

11. The method of claim 1, wherein the needleless injector delivers the metal containing-material into an unguis of the subject.

12. The method of claim 1, wherein the needleless injector delivers the metal containing-material through the unguis of the subject.

13. The method of claim 1, wherein the needleless injector delivers the metal containing-material into tissue adjacent to an unguis of the subject.

14. The method of claim 13, wherein the tissue adjacent to the unguis of the subject comprises skin.

15. The method of claim 13, wherein the needleless injector delivers the metal containing-material through the tissue adjacent to the unguis.

16. The method of claim 15, wherein the tissue adjacent to the unguis of the subject comprises skin.

17. The method of claim 1, wherein the needleless injector delivers the metal containing-material into an unguis of the subject and into tissue adjacent to the unguis of the subject.

18. The method of claim 17, wherein the needleless injector delivers the metal containing-material through the unguis of the subject.

19. The method of claim 18, wherein the needleless injector delivers the metal containing-material through tissue adjacent to an unguis of the subject.

20. The method of claim 17, wherein the needleless injector delivers the metal containing-material through tissue adjacent to an unguis of the subject.

21. The method of claim 1, wherein the subject is a human.